======= GPER1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPER1
  * **<color #00a2e8>Official Name</color>**: G protein-coupled estrogen receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2852|2852]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99527|Q99527]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPER1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPER1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601805|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear fragmentation involved in apoptotic nuclear change|
|positive regulation of cardiac vascular smooth muscle cell differentiation|
|regulation of cardiac vascular smooth muscle cell differentiation|
|apoptotic chromosome condensation|
|estrogen receptor activity|
|positive regulation of inositol trisphosphate biosynthetic process|
|steroid hormone binding|
|cellular response to mineralocorticoid stimulus|
|positive regulation of vascular smooth muscle cell differentiation|
|nuclear membrane organization|
|regulation of inositol trisphosphate biosynthetic process|
|positive regulation of uterine smooth muscle contraction|
|dendritic spine head|
|regulation of uterine smooth muscle contraction|
|positive regulation of smooth muscle cell differentiation|
|dendritic spine membrane|
|positive regulation of inositol phosphate biosynthetic process|
|regulation of vascular smooth muscle cell differentiation|
|regulation of inositol phosphate biosynthetic process|
|negative regulation of vascular smooth muscle cell proliferation|
|positive regulation of endothelial cell apoptotic process|
|positive regulation of neurotransmitter secretion|
|negative regulation of cell cycle arrest|
|apoptotic nuclear changes|
|positive regulation of alcohol biosynthetic process|
|cellular component disassembly involved in execution phase of apoptosis|
|positive regulation of G protein-coupled receptor signaling pathway|
|positive regulation of cardiocyte differentiation|
|steroid binding|
|neuronal action potential|
|positive regulation of release of cytochrome c from mitochondria|
|positive regulation of smooth muscle contraction|
|positive regulation of epidermal growth factor receptor signaling pathway|
|regulation of smooth muscle cell differentiation|
|positive regulation of epithelial cell apoptotic process|
|response to mineralocorticoid|
|positive regulation of ERBB signaling pathway|
|hippocampal mossy fiber to CA3 synapse|
|presynaptic active zone|
|dendritic shaft|
|cellular response to estradiol stimulus|
|positive regulation of neurotransmitter transport|
|positive regulation of release of sequestered calcium ion into cytosol|
|chromosome condensation|
|negative regulation of smooth muscle cell proliferation|
|positive regulation of muscle contraction|
|negative regulation of protein kinase B signaling|
|negative regulation of fat cell differentiation|
|regulation of release of cytochrome c from mitochondria|
|positive regulation of extrinsic apoptotic signaling pathway|
|negative regulation of lipid biosynthetic process|
|regulation of endothelial cell apoptotic process|
|regulation of cardiocyte differentiation|
|regulation of vascular smooth muscle cell proliferation|
|steroid hormone receptor activity|
|axon terminus|
|nuclear envelope organization|
|execution phase of apoptosis|
|positive regulation of calcium ion transport into cytosol|
|positive regulation of protein localization to plasma membrane|
|transmission of nerve impulse|
|positive regulation of blood vessel diameter|
|positive regulation of cellular carbohydrate metabolic process|
|cellular response to corticosteroid stimulus|
|regulation of smooth muscle contraction|
|positive regulation of protein localization to cell periphery|
|negative regulation of ERK1 and ERK2 cascade|
|intracellular steroid hormone receptor signaling pathway|
|cellular response to glucose stimulus|
|positive regulation of calcium ion transmembrane transport|
|cellular response to hexose stimulus|
|positive regulation of insulin secretion|
|cellular response to monosaccharide stimulus|
|presynaptic membrane|
|regulation of alcohol biosynthetic process|
|regulation of release of sequestered calcium ion into cytosol|
|regulation of epithelial cell apoptotic process|
|positive regulation of carbohydrate metabolic process|
|cellular response to carbohydrate stimulus|
|negative regulation of lipid metabolic process|
|regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of muscle cell differentiation|
|cellular glucose homeostasis|
|regulation of ERBB signaling pathway|
|action potential|
|regulation of protein localization to plasma membrane|
|regulation of carbohydrate biosynthetic process|
|positive regulation of peptide hormone secretion|
|keratin filament|
|regulation of calcium ion transport into cytosol|
|mitochondrial membrane|
|regulation of neurotransmitter secretion|
|regulation of cell cycle arrest|
|regulation of protein localization to cell periphery|
|positive regulation of mitochondrion organization|
|recycling endosome|
|regulation of phosphatidylinositol 3-kinase signaling|
|steroid hormone mediated signaling pathway|
|negative regulation of DNA metabolic process|
|positive regulation of calcium ion transport|
|positive regulation of protein localization to membrane|
|regulation of fat cell differentiation|
|regulation of sequestering of calcium ion|
|positive regulation of hormone secretion|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|nucleus organization|
|regulation of smooth muscle cell proliferation|
|multicellular organismal signaling|
|response to estradiol|
|negative regulation of inflammatory response|
|positive regulation of small molecule metabolic process|
|response to glucose|
|regulation of blood vessel diameter|
|regulation of cellular carbohydrate metabolic process|
|regulation of tube diameter|
|regulation of tube size|
|positive regulation of cation transmembrane transport|
|response to hexose|
|regulation of neurotransmitter transport|
|cytoplasmic vesicle membrane|
|regulation of G protein-coupled receptor signaling pathway|
|cAMP-mediated signaling|
|regulation of calcium ion transmembrane transport|
|response to monosaccharide|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of synaptic transmission|
|regulation of muscle cell differentiation|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of ion transmembrane transport|
|regulation of muscle contraction|
|response to corticosteroid|
|intracellular receptor signaling pathway|
|negative regulation of MAPK cascade|
|vascular process in circulatory system|
|trans-Golgi network|
|hormone-mediated signaling pathway|
|cyclic-nucleotide-mediated signaling|
|response to carbohydrate|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|negative regulation of leukocyte activation|
|DNA packaging|
|regulation of insulin secretion|
|nuclear envelope|
|regulation of mitochondrion organization|
|positive regulation of vasculature development|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of lipid biosynthetic process|
|cellular response to steroid hormone stimulus|
|regulation of protein localization to membrane|
|positive regulation of peptidase activity|
|negative regulation of cell activation|
|positive regulation of transmembrane transport|
|regulation of carbohydrate metabolic process|
|negative regulation of defense response|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of peptide hormone secretion|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of protein kinase B signaling|
|regulation of muscle system process|
|cellular response to tumor necrosis factor|
|regulation of cysteine-type endopeptidase activity|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|postsynaptic density|
|early endosome|
|response to tumor necrosis factor|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|axon|
|DNA conformation change|
|regulation of vasculature development|
|positive regulation of cellular protein localization|
|negative regulation of cell cycle process|
|cellular response to peptide|
|response to steroid hormone|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|regulation of inflammatory response|
|second-messenger-mediated signaling|
|regulation of neurotransmitter levels|
|regulation of DNA metabolic process|
|positive regulation of proteolysis|
|negative regulation of response to external stimulus|
|positive regulation of cell cycle|
|regulation of metal ion transport|
|blood circulation|
|response to peptide hormone|
|chromatin binding|
|circulatory system process|
|regulation of lipid metabolic process|
|regulation of apoptotic signaling pathway|
|cellular component disassembly|
|positive regulation of secretion by cell|
|negative regulation of protein phosphorylation|
|regulation of endopeptidase activity|
|endomembrane system organization|
|dendrite|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|regulation of membrane potential|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|regulation of peptidase activity|
|calcium ion homeostasis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|response to peptide|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|regulation of anatomical structure size|
|cellular response to lipid|
|positive regulation of cell motility|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|cell junction|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|negative regulation of cell cycle|
|regulation of system process|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|Golgi membrane|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|regulation of cell activation|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|regulation of ion transport|
|regulation of protein transport|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|regulation of proteolysis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of secretion|
|regulation of neurogenesis|
|regulation of cell migration|
|response to lipid|
|membrane organization|
|cellular homeostasis|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|defense response to other organism|
|positive regulation of cell differentiation|
|regulation of locomotion|
|Golgi apparatus|
|positive regulation of transport|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|chromosome organization|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.71|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.93|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12345
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPER1 Expression in NALM6 Cells: 6.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>