======= GPR107 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPR107
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor 107
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57720|57720]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VW38|Q5VW38]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR107&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR107|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618490|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins. {ECO:0000269|PubMed:25031321}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lung 7-TM R|
|GpcrRhopsn4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|clathrin heavy chain binding|
|clathrin-dependent endocytosis|
|clathrin-coated vesicle|
|receptor-mediated endocytosis|
|early endosome|
|endocytosis|
|import into cell|
|Golgi apparatus|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-5.73|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-4.98|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-4.88|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-4.6|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-4.51|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-4.18|
|[[:results:exp169|BH1 1μM R04 exp169]]|-4.04|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-3.92|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-3.86|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-3.8|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-3.67|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-3.51|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-3.4|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-3.22|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-3.2|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-3.16|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-3.15|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-3.15|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-3.13|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-3.05|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-3.04|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-3.01|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.98|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.97|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.97|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.93|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.9|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.73|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-2.56|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.55|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.54|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.42|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-2.42|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.37|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-2.34|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.34|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.33|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-2.33|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.26|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-2.26|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.23|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2.17|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-2.15|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.12|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-2.1|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.06|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-2.03|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.02|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.01|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.99|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.99|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.95|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.95|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.92|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.91|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-1.87|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.85|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.82|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.81|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:j:jtb|JTB]]|0.653|
|[[:human genes:a:arl1|ARL1]]|0.627|
|[[:human genes:c:cog7|COG7]]|0.555|
|[[:human genes:z:zfat|ZFAT]]|0.553|
|[[:human genes:c:cog5|COG5]]|0.549|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.518|
|[[:human genes:u:unc50|UNC50]]|0.507|
|[[:human genes:t:tssc1|TSSC1]]|0.495|
|[[:human genes:c:chka|CHKA]]|0.491|
|[[:human genes:s:scyl1|SCYL1]]|0.486|
|[[:human genes:m:mbtps1|MBTPS1]]|0.484|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.474|
|[[:human genes:s:sptlc1|SPTLC1]]|0.473|
|[[:human genes:r:rab1b|RAB1B]]|0.462|
|[[:human genes:r:rgp1|RGP1]]|0.458|
|[[:human genes:f:flvcr1|FLVCR1]]|0.457|
|[[:human genes:w:wdr7|WDR7]]|0.455|
|[[:human genes:p:pcyt1a|PCYT1A]]|0.449|
|[[:human genes:c:commd3|COMMD3]]|0.446|
|[[:human genes:a:atp6v0a2|ATP6V0A2]]|0.443|
|[[:human genes:c:cog6|COG6]]|0.436|
|[[:human genes:s:slc39a9|SLC39A9]]|0.43|
|[[:human genes:a:arpc4|ARPC4]]|0.429|
|[[:human genes:p:pi4kb|PI4KB]]|0.426|
|[[:human genes:u:usp32|USP32]]|0.422|
|[[:human genes:t:tbc1d22b|TBC1D22B]]|0.421|
|[[:human genes:c:ccdc132|CCDC132]]|0.414|
|[[:human genes:a:apba3|APBA3]]|0.414|
|[[:human genes:k:kiaa1432|KIAA1432]]|0.413|
|[[:human genes:s:scap|SCAP]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16811
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR107 Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>