======= GPR56 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADGRG1
  * **<color #00a2e8>Official Name</color>**: adhesion G protein-coupled receptor G1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9289|9289]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y653|Q9Y653]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR56&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR56|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604110|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 2|
|GPS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glial limiting end-foot|
|vascular endothelial growth factor production|
|cerebral cortex regionalization|
|seminiferous tubule development|
|negative regulation of neuron migration|
|layer formation in cerebral cortex|
|telencephalon regionalization|
|protein kinase C signaling|
|telencephalon glial cell migration|
|cerebral cortex radial glia guided migration|
|forebrain regionalization|
|extracellular matrix binding|
|cerebral cortex radially oriented cell migration|
|positive regulation of Rho protein signal transduction|
|glial cell migration|
|regulation of neuron migration|
|cerebral cortex cell migration|
|positive regulation of neural precursor cell proliferation|
|telencephalon cell migration|
|forebrain cell migration|
|positive regulation of Ras protein signal transduction|
|collagen binding|
|positive regulation of small GTPase mediated signal transduction|
|Rho protein signal transduction|
|regulation of neural precursor cell proliferation|
|cerebral cortex development|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|male gonad development|
|development of primary male sexual characteristics|
|regulation of Rho protein signal transduction|
|cAMP-mediated signaling|
|cytokine production|
|male sex differentiation|
|heparin binding|
|cyclic-nucleotide-mediated signaling|
|pallium development|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|gonad development|
|gliogenesis|
|development of primary sexual characteristics|
|membrane raft|
|regulation of Ras protein signal transduction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|Ras protein signal transduction|
|telencephalon development|
|negative regulation of cell migration|
|sex differentiation|
|negative regulation of cell motility|
|negative regulation of neurogenesis|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|angiogenesis|
|small GTPase mediated signal transduction|
|negative regulation of locomotion|
|regionalization|
|negative regulation of cell development|
|second-messenger-mediated signaling|
|regulation of small GTPase mediated signal transduction|
|forebrain development|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|reproductive structure development|
|reproductive system development|
|pattern specification process|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|tube morphogenesis|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|negative regulation of cell differentiation|
|G protein-coupled receptor activity|
|brain development|
|head development|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of intracellular signal transduction|
|cell motility|
|localization of cell|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of signal transduction|
|intracellular signal transduction|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.74|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3009
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR56 Expression in NALM6 Cells: 1.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>