======= GPR98 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADGRV1
  * **<color #00a2e8>Official Name</color>**: adhesion G protein-coupled receptor V1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84059|84059]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WXG9|Q8WXG9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR98&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR98|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602851|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor that may have an important role in the development of the central nervous system.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Calx-beta|
|EPTP|
|GPS|
|7tm 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenylate cyclase inhibitor activity|
|USH2 complex|
|maintenance of animal organ identity|
|stereocilia ankle link|
|stereocilium membrane|
|periciliary membrane compartment|
|stereocilia ankle link complex|
|self proteolysis|
|positive regulation of protein kinase C signaling|
|positive regulation of protein kinase A signaling|
|detection of mechanical stimulus involved in sensory perception of sound|
|regulation of protein kinase C signaling|
|negative regulation of adenylate cyclase activity|
|negative regulation of cyclase activity|
|regulation of protein kinase A signaling|
|negative regulation of lyase activity|
|G-protein alpha-subunit binding|
|regulation of adenylate cyclase activity|
|inner ear receptor cell stereocilium organization|
|detection of mechanical stimulus involved in sensory perception|
|photoreceptor cell maintenance|
|positive regulation of bone mineralization|
|inner ear receptor cell development|
|regulation of cyclase activity|
|detection of mechanical stimulus|
|regulation of lyase activity|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|photoreceptor inner segment|
|inner ear receptor cell differentiation|
|mechanoreceptor differentiation|
|regulation of bone mineralization|
|retina homeostasis|
|hydrolase activity|
|cellular response to calcium ion|
|positive regulation of ossification|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|detection of external stimulus|
|detection of abiotic stimulus|
|sensory perception of sound|
|response to calcium ion|
|sensory perception of mechanical stimulus|
|regulation of ossification|
|tissue homeostasis|
|cellular response to metal ion|
|inner ear development|
|receptor complex|
|response to mechanical stimulus|
|cellular response to inorganic substance|
|ear development|
|visual perception|
|sensory perception of light stimulus|
|synapse|
|regulation of protein stability|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|response to metal ion|
|cell-cell adhesion|
|response to inorganic substance|
|detection of stimulus involved in sensory perception|
|sensory organ development|
|cell surface|
|neuron projection development|
|detection of stimulus|
|negative regulation of cell differentiation|
|calcium ion binding|
|G protein-coupled receptor activity|
|negative regulation of catalytic activity|
|neuron development|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|sensory perception|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|response to abiotic stimulus|
|cell projection organization|
|proteolysis|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|nervous system process|
|generation of neurons|
|establishment of protein localization|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.84|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.74|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.79|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.91|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|2.22|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12957
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR98 Expression in NALM6 Cells: 1.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>