======= GPRIN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPRIN2
  * **<color #00a2e8>Official Name</color>**: G protein regulated inducer of neurite outgrowth 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9721|9721]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60269|O60269]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPRIN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPRIN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611240|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in neurite outgrowth. {ECO:0000269|PubMed:10480904}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.72|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|2|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.13|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:twistnb|TWISTNB]]|0.506|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.491|
|[[:human genes:t:ticrr|TICRR]]|0.487|
|[[:human genes:a:ankle1|ANKLE1]]|0.483|
|[[:human genes:o:orc1|ORC1]]|0.476|
|[[:human genes:p:polr2j3|POLR2J3]]|0.468|
|[[:human genes:a:ankle2|ANKLE2]]|0.462|
|[[:human genes:t:tceb3c|TCEB3C]]|0.462|
|[[:human genes:n:npipb5|NPIPB5]]|0.457|
|[[:human genes:k:kctd17|KCTD17]]|0.455|
|[[:human genes:p:psma6|PSMA6]]|0.454|
|[[:human genes:m:med17|MED17]]|0.451|
|[[:human genes:v:vps54|VPS54]]|0.448|
|[[:human genes:g:gid4|GID4]]|0.444|
|[[:human genes:c:c14orf93|C14orf93]]|0.443|
|[[:human genes:c:chd4|CHD4]]|0.442|
|[[:human genes:p:psmb4|PSMB4]]|0.442|
|[[:human genes:t:tfip11|TFIP11]]|0.44|
|[[:human genes:s:supt5h|SUPT5H]]|0.439|
|[[:human genes:w:wdr75|WDR75]]|0.439|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.438|
|[[:human genes:v:vasn|VASN]]|0.437|
|[[:human genes:f:fbxo5|FBXO5]]|0.437|
|[[:human genes:p:pan3|PAN3]]|0.434|
|[[:human genes:z:znf541|ZNF541]]|0.432|
|[[:human genes:r:rps2|RPS2]]|0.429|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.428|
|[[:human genes:m:myo1h|MYO1H]]|0.428|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.427|
|[[:human genes:c:cactin|CACTIN]]|0.423|
|[[:human genes:m:med14|MED14]]|0.422|
|[[:human genes:m:mt1e|MT1E]]|0.42|
|[[:human genes:d:disp2|DISP2]]|0.42|
|[[:human genes:p:plk1|PLK1]]|0.419|
|[[:human genes:r:rrp15|RRP15]]|0.419|
|[[:human genes:c:cdc6|CDC6]]|0.415|
|[[:human genes:s:supt6h|SUPT6H]]|0.415|
|[[:human genes:a:aqr|AQR]]|0.414|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.413|
|[[:human genes:n:nol12|NOL12]]|0.412|
|[[:human genes:c:clasp1|CLASP1]]|0.412|
|[[:human genes:d:dtl|DTL]]|0.411|
|[[:human genes:d:dnm2|DNM2]]|0.411|
|[[:human genes:a:ahctf1|AHCTF1]]|0.41|
|[[:human genes:p:polr2f|POLR2F]]|0.41|
|[[:human genes:z:znf574|ZNF574]]|0.409|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.409|
|[[:human genes:p:pcf11|PCF11]]|0.409|
|[[:human genes:p:psmd11|PSMD11]]|0.408|
|[[:human genes:c:copb2|COPB2]]|0.407|
|[[:human genes:t:tonsl|TONSL]]|0.406|
|[[:human genes:d:ddtl|DDTL]]|0.406|
|[[:human genes:c:cbwd3|CBWD3]]|0.405|
|[[:human genes:s:sf3a1|SF3A1]]|0.403|
|[[:human genes:s:snip1|SNIP1]]|0.403|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.403|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.403|
|[[:human genes:a:aamp|AAMP]]|0.401|
|[[:human genes:i:iscu|ISCU]]|0.401|
|[[:human genes:c:cgb2|CGB2]]|0.401|
|[[:human genes:n:nbpf10|NBPF10]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2155
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPRIN2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>