======= GPX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPX1
  * **<color #00a2e8>Official Name</color>**: glutathione peroxidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2876|2876]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07203|P07203]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138320|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes X and 21. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Protects the hemoglobin in erythrocytes from oxidative breakdown.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GSHPx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myoblast proliferation|
|response to symbiont|
|response to symbiotic bacterium|
|Lewy body|
|response to selenium ion|
|negative regulation of inflammatory response to antigenic stimulus|
|protein oxidation|
|UV protection|
|angiogenesis involved in wound healing|
|lipoxygenase pathway|
|regulation of mammary gland epithelial cell proliferation|
|negative regulation of release of cytochrome c from mitochondria|
|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|response to hydroperoxide|
|glutathione peroxidase activity|
|skeletal muscle fiber development|
|regulation of inflammatory response to antigenic stimulus|
|hydrogen peroxide catabolic process|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|myotube cell development|
|vasodilation|
|blood vessel endothelial cell migration|
|temperature homeostasis|
|peroxidase activity|
|skeletal muscle tissue regeneration|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|hydrogen peroxide metabolic process|
|negative regulation of oxidative stress-induced cell death|
|purine nucleotide catabolic process|
|negative regulation of cellular response to oxidative stress|
|negative regulation of response to oxidative stress|
|regulation of release of cytochrome c from mitochondria|
|endothelial cell development|
|purine-containing compound catabolic process|
|negative regulation of mitochondrion organization|
|antibiotic catabolic process|
|glutathione metabolic process|
|response to gamma radiation|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|myotube differentiation|
|positive regulation of blood vessel diameter|
|muscle fiber development|
|cofactor catabolic process|
|regulation of oxidative stress-induced cell death|
|tissue regeneration|
|endothelial cell migration|
|nucleotide catabolic process|
|nucleoside phosphate catabolic process|
|regulation of cellular response to oxidative stress|
|triglyceride metabolic process|
|cell redox homeostasis|
|interaction with symbiont|
|endothelial cell differentiation|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|epithelial cell migration|
|regulation of response to oxidative stress|
|heart contraction|
|epithelium migration|
|negative regulation of cysteine-type endopeptidase activity|
|cellular oxidant detoxification|
|tissue migration|
|endothelium development|
|negative regulation of intrinsic apoptotic signaling pathway|
|acylglycerol metabolic process|
|heart process|
|neutral lipid metabolic process|
|cellular detoxification|
|negative regulation of extrinsic apoptotic signaling pathway|
|antibiotic metabolic process|
|fat cell differentiation|
|nucleobase-containing small molecule biosynthetic process|
|icosanoid metabolic process|
|reactive oxygen species metabolic process|
|response to hydrogen peroxide|
|skeletal muscle tissue development|
|organophosphate catabolic process|
|detoxification|
|SH3 domain binding|
|skeletal muscle organ development|
|striated muscle cell development|
|negative regulation of inflammatory response|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|response to UV|
|drug catabolic process|
|sensory perception of sound|
|muscle cell development|
|negative regulation of immune response|
|response to ionizing radiation|
|regulation of extrinsic apoptotic signaling pathway|
|regeneration|
|regulation of intrinsic apoptotic signaling pathway|
|positive regulation of protein kinase B signaling|
|sensory perception of mechanical stimulus|
|fatty acid derivative metabolic process|
|vascular process in circulatory system|
|ameboidal-type cell migration|
|regulation of mitochondrion organization|
|regulation of proteasomal protein catabolic process|
|epithelial cell development|
|response to reactive oxygen species|
|positive regulation of supramolecular fiber organization|
|cellular modified amino acid metabolic process|
|striated muscle cell differentiation|
|negative regulation of defense response|
|cellular response to toxic substance|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein kinase B signaling|
|negative regulation of apoptotic signaling pathway|
|regulation of gene expression, epigenetic|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|muscle cell differentiation|
|regulation of cellular protein catabolic process|
|negative regulation of peptidase activity|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|response to xenobiotic stimulus|
|response to antibiotic|
|response to light stimulus|
|angiogenesis|
|fatty acid metabolic process|
|multicellular organismal homeostasis|
|purine nucleotide metabolic process|
|regulation of epithelial cell proliferation|
|regulation of inflammatory response|
|regulation of supramolecular fiber organization|
|negative regulation of proteolysis|
|negative regulation of response to external stimulus|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|negative regulation of organelle organization|
|nucleobase-containing compound catabolic process|
|glycerolipid metabolic process|
|regulation of protein catabolic process|
|response to oxidative stress|
|developmental growth|
|blood circulation|
|growth|
|circulatory system process|
|regulation of apoptotic signaling pathway|
|blood vessel morphogenesis|
|regulation of endopeptidase activity|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|cofactor metabolic process|
|response to radiation|
|negative regulation of immune system process|
|aromatic compound catabolic process|
|regulation of peptidase activity|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|negative regulation of hydrolase activity|
|muscle structure development|
|wound healing|
|organic cyclic compound catabolic process|
|blood vessel development|
|drug metabolic process|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|peptide metabolic process|
|monocarboxylic acid metabolic process|
|response to inorganic substance|
|nucleobase-containing small molecule metabolic process|
|cell population proliferation|
|response to wounding|
|small molecule biosynthetic process|
|tube morphogenesis|
|epithelial cell differentiation|
|response to bacterium|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of defense response|
|symbiotic process|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|tube development|
|circulatory system development|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|cell migration|
|sensory perception|
|regulation of catabolic process|
|negative regulation of cell death|
|oxoacid metabolic process|
|positive regulation of intracellular signal transduction|
|response to drug|
|organic acid metabolic process|
|negative regulation of cellular protein metabolic process|
|organonitrogen compound catabolic process|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|epithelium development|
|negative regulation of molecular function|
|regulation of immune response|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.72|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15252
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPX1 Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>