======= GRB10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRB10
  * **<color #00a2e8>Official Name</color>**: growth factor receptor bound protein 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2887|2887]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13322|Q13322]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRB10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRB10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601523|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH2|
|BPS|
|RA|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of glucose import|
|positive regulation of vascular endothelial growth factor receptor signaling pathway|
|negative regulation of glucose transmembrane transport|
|insulin receptor binding|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|negative regulation of insulin receptor signaling pathway|
|negative regulation of cellular response to insulin stimulus|
|SH3/SH2 adaptor activity|
|regulation of glucose import|
|regulation of insulin receptor signaling pathway|
|regulation of cellular response to insulin stimulus|
|regulation of glucose transmembrane transport|
|insulin receptor signaling pathway|
|positive regulation of cold-induced thermogenesis|
|negative regulation of transmembrane transport|
|regulation of cold-induced thermogenesis|
|cellular response to insulin stimulus|
|negative regulation of Wnt signaling pathway|
|response to insulin|
|axon guidance|
|neuron projection guidance|
|cellular response to peptide hormone stimulus|
|regulation of cellular response to growth factor stimulus|
|cellular response to peptide|
|regulation of Wnt signaling pathway|
|axonogenesis|
|response to peptide hormone|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|response to peptide|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|cell projection morphogenesis|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|regulation of transmembrane transport|
|protein-containing complex|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|neuron projection development|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|response to hormone|
|response to organonitrogen compound|
|neuron differentiation|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.78|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.7|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.79|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.8|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.88|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.91|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.8|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8557
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRB10 Expression in NALM6 Cells: 6.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>