======= GRB7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRB7
  * **<color #00a2e8>Official Name</color>**: growth factor receptor bound protein 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2886|2886]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14451|Q14451]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRB7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRB7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601522|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH2|
|BPS|
|RA|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|stress granule assembly|
|ERBB2 signaling pathway|
|negative regulation of insulin receptor signaling pathway|
|negative regulation of cellular response to insulin stimulus|
|epidermal growth factor receptor signaling pathway|
|SH3/SH2 adaptor activity|
|regulation of insulin receptor signaling pathway|
|cytoplasmic stress granule|
|ERBB signaling pathway|
|regulation of cellular response to insulin stimulus|
|phosphatidylinositol binding|
|insulin receptor signaling pathway|
|cell projection|
|negative regulation of translation|
|negative regulation of cellular amide metabolic process|
|cellular response to insulin stimulus|
|response to insulin|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|axon guidance|
|neuron projection guidance|
|cellular response to peptide hormone stimulus|
|cellular response to peptide|
|regulation of translation|
|axonogenesis|
|leukocyte migration|
|response to peptide hormone|
|regulation of cellular amide metabolic process|
|axon development|
|focal adhesion|
|cell morphogenesis involved in neuron differentiation|
|ribonucleoprotein complex biogenesis|
|protein kinase binding|
|response to peptide|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|positive regulation of cell motility|
|posttranscriptional regulation of gene expression|
|positive regulation of cellular component movement|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell morphogenesis involved in differentiation|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|neuron projection development|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|organelle assembly|
|neuron development|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|response to hormone|
|regulation of cell motility|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|identical protein binding|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.13|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.91|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.77|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2590
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRB7 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>