======= GRIK5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRIK5
  * **<color #00a2e8>Official Name</color>**: glutamate ionotropic receptor kainate type subunit 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2901|2901]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16478|Q16478]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRIK5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRIK5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600283|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SBP bac 3|
|ANF receptor|
|Lig chan-Glu bd|
|Lig chan|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|kainate selective glutamate receptor activity|
|kainate selective glutamate receptor complex|
|protein retention in ER lumen|
|regulation of synaptic vesicle fusion to presynaptic active zone membrane|
|maintenance of protein localization in endoplasmic reticulum|
|glutamate receptor activity|
|ionotropic glutamate receptor signaling pathway|
|synaptic transmission, glutamatergic|
|regulation of vesicle fusion|
|hippocampal mossy fiber to CA3 synapse|
|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|
|maintenance of protein localization in organelle|
|glutamate receptor signaling pathway|
|receptor clustering|
|terminal bouton|
|integral component of postsynaptic density membrane|
|positive regulation of neuron apoptotic process|
|integral component of presynaptic membrane|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|presynaptic membrane|
|maintenance of protein location in cell|
|regulation of synaptic vesicle exocytosis|
|cellular response to carbohydrate stimulus|
|localization within membrane|
|PDZ domain binding|
|cellular glucose homeostasis|
|positive regulation of neuron death|
|maintenance of location in cell|
|regulation of postsynaptic membrane potential|
|regulation of neurotransmitter secretion|
|maintenance of protein location|
|regulation of synaptic vesicle cycle|
|SH3 domain binding|
|perikaryon|
|protein localization to endoplasmic reticulum|
|response to glucose|
|response to hexose|
|regulation of neurotransmitter transport|
|response to monosaccharide|
|maintenance of location|
|regulation of regulated secretory pathway|
|response to carbohydrate|
|glucose homeostasis|
|carbohydrate homeostasis|
|postsynaptic membrane|
|regulation of neuron apoptotic process|
|regulation of exocytosis|
|regulation of neuron death|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|protein localization to membrane|
|cell junction|
|regulation of vesicle-mediated transport|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|protein localization to organelle|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of secretion|
|cellular homeostasis|
|regulation of cellular localization|
|ion transmembrane transport|
|endoplasmic reticulum|
|cellular response to oxygen-containing compound|
|identical protein binding|
|chemical homeostasis|
|cell-cell signaling|
|transmembrane transport|
|regulation of organelle organization|
|ion transport|
|nervous system process|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|homeostatic process|
|regulation of cell death|
|establishment of localization in cell|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3508
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRIK5 Expression in NALM6 Cells: 0.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>