======= GRIN2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRIN2A
  * **<color #00a2e8>Official Name</color>**: glutamate ionotropic receptor NMDA type subunit 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2903|2903]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12879|Q12879]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRIN2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRIN2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138253|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). {ECO:0000250|UniProtKB:P35436, ECO:0000250|UniProtKB:Q00959, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:8768735}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NMDAR2 C|
|Lig chan-Glu bd|
|ANF receptor|
|SBP bac 3|
|Lig chan|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|directional locomotion|
|glutamate-gated calcium ion channel activity|
|NMDA glutamate receptor activity|
|excitatory chemical synaptic transmission|
|serotonin metabolic process|
|NMDA selective glutamate receptor complex|
|primary amino compound metabolic process|
|activation of cysteine-type endopeptidase activity|
|sleep|
|postsynaptic density membrane|
|indole-containing compound metabolic process|
|ionotropic glutamate receptor signaling pathway|
|synaptic membrane|
|startle response|
|dopamine metabolic process|
|response to amphetamine|
|protein localization to postsynaptic membrane|
|regulation of NMDA receptor activity|
|cellular response to amyloid-beta|
|zymogen activation|
|catechol-containing compound metabolic process|
|catecholamine metabolic process|
|glutamate receptor signaling pathway|
|response to amine|
|long-term synaptic potentiation|
|visual learning|
|response to amyloid-beta|
|integral component of postsynaptic density membrane|
|response to bronchodilator|
|visual behavior|
|excitatory postsynaptic potential|
|protein localization to synapse|
|regulation of glutamate receptor signaling pathway|
|calcium ion transmembrane import into cytosol|
|chemical synaptic transmission, postsynaptic|
|calcium ion transport into cytosol|
|presynaptic membrane|
|regulation of neurotransmitter receptor activity|
|sensory perception of pain|
|associative learning|
|amyloid-beta binding|
|phenol-containing compound metabolic process|
|cytosolic calcium ion transport|
|neurotransmitter metabolic process|
|regulation of postsynaptic membrane potential|
|neuromuscular process|
|memory|
|synaptic vesicle|
|response to ethanol|
|negative regulation of protein catabolic process|
|learning|
|calcium-mediated signaling|
|dendritic spine|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of synaptic transmission|
|protein processing|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|positive regulation of endopeptidase activity|
|regulation of synaptic plasticity|
|positive regulation of peptidase activity|
|ammonium ion metabolic process|
|calcium ion transmembrane transport|
|protein maturation|
|protein localization to cell periphery|
|response to alcohol|
|regulation of cysteine-type endopeptidase activity|
|calcium ion transport|
|postsynaptic density|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|divalent metal ion transport|
|cognition|
|response to xenobiotic stimulus|
|divalent inorganic cation transport|
|response to antibiotic|
|response to light stimulus|
|negative regulation of catabolic process|
|cellular response to peptide|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of proteolysis|
|regulation of protein catabolic process|
|regulation of endopeptidase activity|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of peptidase activity|
|calcium ion homeostasis|
|organic hydroxy compound metabolic process|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|divalent inorganic cation homeostasis|
|drug metabolic process|
|response to toxic substance|
|cell junction|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|behavior|
|response to wounding|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|positive regulation of cell death|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of proteolysis|
|brain development|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|head development|
|ion homeostasis|
|cation transport|
|zinc ion binding|
|cellular homeostasis|
|ion transmembrane transport|
|sensory perception|
|central nervous system development|
|regulation of catabolic process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|cell-cell signaling|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|proteolysis|
|regulation of hydrolase activity|
|transmembrane transport|
|locomotion|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of transport|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9054
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRIN2A Expression in NALM6 Cells: 0.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>