======= GRIPAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRIPAP1
  * **<color #00a2e8>Official Name</color>**: GRIP1 associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56850|56850]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q4V328|Q4V328]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRIPAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRIPAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300408|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of recycling endosome localization within postsynapse|
|extrinsic component of postsynaptic early endosome membrane|
|regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane|
|regulation of endosome to plasma membrane protein transport|
|postsynaptic recycling endosome|
|neurotransmitter receptor transport, endosome to postsynaptic membrane|
|neurotransmitter receptor transport, endosome to plasma membrane|
|endosome to plasma membrane protein transport|
|regulation of modification of synaptic structure|
|neurotransmitter receptor transport to postsynaptic membrane|
|neurotransmitter receptor transport to plasma membrane|
|regulation of receptor localization to synapse|
|establishment of protein localization to postsynaptic membrane|
|regulation of synaptic vesicle recycling|
|regulation of protein localization to synapse|
|retrograde transport, endosome to plasma membrane|
|protein localization to postsynaptic membrane|
|neurotransmitter receptor transport|
|receptor localization to synapse|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|establishment of protein localization to plasma membrane|
|protein localization to synapse|
|recycling endosome membrane|
|vesicle-mediated transport to the plasma membrane|
|regulation of protein localization to plasma membrane|
|regulation of synaptic vesicle cycle|
|regulation of protein localization to cell periphery|
|blood microparticle|
|protein localization to plasma membrane|
|regulation of protein localization to membrane|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|protein localization to cell periphery|
|endosomal transport|
|regulation of intracellular protein transport|
|protein-containing complex localization|
|establishment of protein localization to membrane|
|axon|
|glutamatergic synapse|
|regulation of intracellular transport|
|dendrite|
|protein localization to membrane|
|regulation of cellular protein localization|
|cell junction|
|regulation of vesicle-mediated transport|
|intracellular membrane-bounded organelle|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|molecular function|
|regulation of cellular localization|
|intracellular protein transport|
|regulation of protein localization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.8|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7731
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRIPAP1 Expression in NALM6 Cells: 6.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>