======= GRM7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GRM7
  * **<color #00a2e8>Official Name</color>**: glutamate metabotropic receptor 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2917|2917]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14831|Q14831]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GRM7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GRM7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604101|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:9473604}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 3|
|ANF receptor|
|NCD3G|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|group III metabotropic glutamate receptor activity|
|adenylate cyclase inhibitor activity|
|asymmetric synapse|
|serine binding|
|negative regulation of glutamate secretion|
|adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway|
|negative regulation of amino acid transport|
|G protein-coupled glutamate receptor signaling pathway|
|glutamate receptor activity|
|regulation of glutamate secretion|
|negative regulation of organic acid transport|
|negative regulation of amine transport|
|negative regulation of anion transport|
|behavioral fear response|
|behavioral defense response|
|regulation of amino acid transport|
|fear response|
|presynaptic active zone|
|dendritic shaft|
|calcium channel regulator activity|
|regulation of cyclase activity|
|glutamate receptor signaling pathway|
|regulation of organic acid transport|
|multicellular organismal response to stress|
|regulation of synaptic transmission, glutamatergic|
|presynaptic membrane|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|regulation of amine transport|
|regulation of anion transport|
|cell cortex|
|sensory perception of sound|
|negative regulation of ion transport|
|sensory perception of mechanical stimulus|
|postsynaptic membrane|
|negative regulation of secretion by cell|
|receptor complex|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|negative regulation of secretion|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|axon|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|negative regulation of transport|
|behavior|
|regulation of ion transport|
|regulation of secretion by cell|
|regulation of secretion|
|sensory perception|
|cell-cell signaling|
|G protein-coupled receptor signaling pathway|
|defense response|
|nervous system process|
|integral component of plasma membrane|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp73|LJH685 5μM R02 exp73]]|-2.07|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5289
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GRM7 Expression in NALM6 Cells: 0.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>