======= GSKIP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GSKIP
  * **<color #00a2e8>Official Name</color>**: GSK3B interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51527|51527]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0R6|Q9P0R6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GSKIP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GSKIP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616605|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:27484798, PubMed:25920809, PubMed:16981698). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:27484798, PubMed:16981698). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702). {ECO:0000269|PubMed:16981698, ECO:0000269|PubMed:19830702, ECO:0000269|PubMed:25920809, ECO:0000269|PubMed:27484798}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF727|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intrinsic apoptotic signaling pathway in response to oxidative stress|
|cell death in response to oxidative stress|
|protein kinase A regulatory subunit binding|
|protein kinase A binding|
|protein kinase inhibitor activity|
|beta-catenin binding|
|positive regulation of canonical Wnt signaling pathway|
|intrinsic apoptotic signaling pathway|
|positive regulation of Wnt signaling pathway|
|negative regulation of protein kinase activity|
|cellular response to oxidative stress|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|regulation of canonical Wnt signaling pathway|
|apoptotic signaling pathway|
|regulation of Wnt signaling pathway|
|response to oxidative stress|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|protein kinase binding|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|apoptotic process|
|regulation of transferase activity|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.75|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.8|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.81|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.86|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:y:ypel5|YPEL5]]|0.489|
|[[:human genes:g:gsk3b|GSK3B]]|0.464|
|[[:human genes:w:wdr26|WDR26]]|0.449|
|[[:human genes:f:fam122a|FAM122A]]|0.438|
|[[:human genes:m:memo1|MEMO1]]|0.415|
|[[:human genes:g:glyr1|GLYR1]]|0.408|
|[[:human genes:p:pcgf1|PCGF1]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18341
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GSKIP Expression in NALM6 Cells: 3.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>