======= GSPT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GSPT1
  * **<color #00a2e8>Official Name</color>**: G1 to S phase transition 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2935|2935]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15170|P15170]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GSPT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GSPT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139259|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GTP EFTU D2|
|GTP EFTU D3|
|GTP EFTU|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic translational termination|
|translation release factor complex|
|translation release factor activity|
|cytoplasmic translation|
|translational termination|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|protein alkylation|
|protein methylation|
|cellular protein complex disassembly|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|protein-containing complex disassembly|
|RNA catabolic process|
|macromolecule methylation|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|methylation|
|GTPase activity|
|nucleobase-containing compound catabolic process|
|translation|
|GTP binding|
|cellular component disassembly|
|peptide biosynthetic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mitotic cell cycle process|
|mitotic cell cycle|
|mRNA metabolic process|
|cellular amide metabolic process|
|cellular macromolecule catabolic process|
|cell cycle process|
|macromolecule catabolic process|
|cell cycle|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.16|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.71|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.74|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.426|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 686/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|26/28|
|bone|23/26|
|breast|32/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|18/20|
|lung|69/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|14/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1415
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GSPT1 Expression in NALM6 Cells: 7.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>