======= GTF2A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTF2A2
  * **<color #00a2e8>Official Name</color>**: general transcription factor IIA subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2958|2958]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52657|P52657]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTF2A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTF2A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600519|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269|PubMed:11030333}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TFIIA gamma C|
|TFIIA gamma N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription factor TFIIA complex|
|RNA polymerase II preinitiation complex assembly|
|RNA polymerase II general transcription initiation factor activity|
|TBP-class protein binding|
|transcription preinitiation complex assembly|
|RNA polymerase II repressing transcription factor binding|
|transcription factor TFIID complex|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|transcription initiation from RNA polymerase II promoter|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|protein-DNA complex subunit organization|
|positive regulation of DNA-binding transcription factor activity|
|transcription coactivator activity|
|transcription factor binding|
|regulation of DNA-binding transcription factor activity|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|cell junction|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|protein homodimerization activity|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-2.31|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-2.15|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.87|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.8|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.79|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.73|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.7|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.7|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.82|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.92|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.92|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.39|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dpagt1|DPAGT1]]|0.546|
|[[:human genes:t:thg1l|THG1L]]|0.528|
|[[:human genes:p:pmm2|PMM2]]|0.528|
|[[:human genes:r:rptor|RPTOR]]|0.5|
|[[:human genes:w:wdr24|WDR24]]|0.492|
|[[:human genes:r:rnmt|RNMT]]|0.489|
|[[:human genes:g:gmppb|GMPPB]]|0.487|
|[[:human genes:c:cbfb|CBFB]]|0.485|
|[[:human genes:d:dohh|DOHH]]|0.482|
|[[:human genes:s:srp14|SRP14]]|0.474|
|[[:human genes:u:utp23|UTP23]]|0.47|
|[[:human genes:a:alg1|ALG1]]|0.46|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.46|
|[[:human genes:w:wdr59|WDR59]]|0.455|
|[[:human genes:t:triap1|TRIAP1]]|0.449|
|[[:human genes:a:alg2|ALG2]]|0.445|
|[[:human genes:p:pelo|PELO]]|0.438|
|[[:human genes:c:ccdc101|CCDC101]]|0.438|
|[[:human genes:g:gnb1l|GNB1L]]|0.436|
|[[:human genes:u:uap1|UAP1]]|0.434|
|[[:human genes:t:trmt10a|TRMT10A]]|0.432|
|[[:human genes:p:ppa2|PPA2]]|0.426|
|[[:human genes:r:rpia|RPIA]]|0.425|
|[[:human genes:n:nae1|NAE1]]|0.421|
|[[:human genes:m:med16|MED16]]|0.42|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.42|
|[[:human genes:a:alg13|ALG13]]|0.418|
|[[:human genes:l:lsm10|LSM10]]|0.418|
|[[:human genes:c:chchd4|CHCHD4]]|0.416|
|[[:human genes:g:gfpt1|GFPT1]]|0.415|
|[[:human genes:a:adsl|ADSL]]|0.413|
|[[:human genes:u:uhrf1|UHRF1]]|0.412|
|[[:human genes:s:sdha|SDHA]]|0.41|
|[[:human genes:t:trmt5|TRMT5]]|0.409|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.409|
|[[:human genes:r:rtcb|RTCB]]|0.408|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.408|
|[[:human genes:r:rpp21|RPP21]]|0.407|
|[[:human genes:t:ten1|TEN1]]|0.406|
|[[:human genes:s:ssbp2|SSBP2]]|0.406|
|[[:human genes:f:fnta|FNTA]]|0.406|
|[[:human genes:r:rft1|RFT1]]|0.406|
|[[:human genes:v:vps41|VPS41]]|0.405|
|[[:human genes:t:taz|TAZ]]|0.403|
|[[:human genes:u:ube2g2|UBE2G2]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 693/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|25/28|
|bone|24/25|
|breast|30/33|
|central nervous system|51/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/15|
|kidney|20/21|
|liver|19/20|
|lung|73/75|
|lymphocyte|13/14|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|5/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1654
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTF2A2 Expression in NALM6 Cells: 6.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>