======= GTF3C2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTF3C2
  * **<color #00a2e8>Official Name</color>**: general transcription factor IIIC subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2976|2976]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUA4|Q8WUA4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTF3C2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTF3C2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604883|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase III general transcription initiation factor activity|
|5S class rRNA transcription by RNA polymerase III|
|transcription factor TFIIIC complex|
|tRNA transcription by RNA polymerase III|
|tRNA transcription|
|rRNA transcription|
|transcription by RNA polymerase III|
|ncRNA transcription|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.8|
|[[:results:exp302|35°C R06 exp302]]|-2.38|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-2.1|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-2.06|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.05|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.93|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.91|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.87|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.84|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.82|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.76|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.75|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.73|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.7|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.3|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rnmt|RNMT]]|0.642|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.626|
|[[:human genes:s:srp68|SRP68]]|0.606|
|[[:human genes:g:gmppb|GMPPB]]|0.597|
|[[:human genes:d:dpagt1|DPAGT1]]|0.59|
|[[:human genes:r:rtcb|RTCB]]|0.585|
|[[:human genes:t:telo2|TELO2]]|0.583|
|[[:human genes:v:vrk1|VRK1]]|0.575|
|[[:human genes:a:alg1|ALG1]]|0.574|
|[[:human genes:m:med16|MED16]]|0.573|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.567|
|[[:human genes:g:gnb1l|GNB1L]]|0.565|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.562|
|[[:human genes:p:pmm2|PMM2]]|0.557|
|[[:human genes:t:trmt5|TRMT5]]|0.554|
|[[:human genes:a:alg5|ALG5]]|0.551|
|[[:human genes:g:gemin5|GEMIN5]]|0.55|
|[[:human genes:a:aars|AARS]]|0.548|
|[[:human genes:m:mapk14|MAPK14]]|0.543|
|[[:human genes:s:srp14|SRP14]]|0.543|
|[[:human genes:t:tti2|TTI2]]|0.542|
|[[:human genes:e:eif4e|EIF4E]]|0.542|
|[[:human genes:p:polr3h|POLR3H]]|0.541|
|[[:human genes:s:srp72|SRP72]]|0.539|
|[[:human genes:o:otud5|OTUD5]]|0.535|
|[[:human genes:e:exoc4|EXOC4]]|0.526|
|[[:human genes:t:triap1|TRIAP1]]|0.526|
|[[:human genes:c:ccdc101|CCDC101]]|0.526|
|[[:human genes:t:thg1l|THG1L]]|0.525|
|[[:human genes:c:cct7|CCT7]]|0.523|
|[[:human genes:g:gfpt1|GFPT1]]|0.519|
|[[:human genes:h:hspd1|HSPD1]]|0.517|
|[[:human genes:r:rptor|RPTOR]]|0.517|
|[[:human genes:r:rad1|RAD1]]|0.511|
|[[:human genes:t:tti1|TTI1]]|0.51|
|[[:human genes:d:dad1|DAD1]]|0.51|
|[[:human genes:n:nae1|NAE1]]|0.505|
|[[:human genes:u:uap1|UAP1]]|0.505|
|[[:human genes:n:nars|NARS]]|0.5|
|[[:human genes:d:dhdds|DHDDS]]|0.499|
|[[:human genes:c:cbfb|CBFB]]|0.498|
|[[:human genes:p:ppp4c|PPP4C]]|0.498|
|[[:human genes:a:atxn10|ATXN10]]|0.498|
|[[:human genes:r:rpp21|RPP21]]|0.497|
|[[:human genes:d:dhps|DHPS]]|0.496|
|[[:human genes:o:osgep|OSGEP]]|0.495|
|[[:human genes:e:eprs|EPRS]]|0.495|
|[[:human genes:a:adsl|ADSL]]|0.495|
|[[:human genes:t:tmem41b|TMEM41B]]|0.487|
|[[:human genes:u:uxt|UXT]]|0.486|
|[[:human genes:l:lsmd1|LSMD1]]|0.485|
|[[:human genes:w:wdr24|WDR24]]|0.485|
|[[:human genes:t:tsen54|TSEN54]]|0.482|
|[[:human genes:s:slc35b1|SLC35B1]]|0.481|
|[[:human genes:a:alg13|ALG13]]|0.48|
|[[:human genes:n:nsmce1|NSMCE1]]|0.479|
|[[:human genes:p:polr3b|POLR3B]]|0.477|
|[[:human genes:p:pelo|PELO]]|0.476|
|[[:human genes:e:eny2|ENY2]]|0.475|
|[[:human genes:y:yars|YARS]]|0.47|
|[[:human genes:d:ddx20|DDX20]]|0.466|
|[[:human genes:t:trnt1|TRNT1]]|0.466|
|[[:human genes:z:znf259|ZNF259]]|0.466|
|[[:human genes:u:uhrf1|UHRF1]]|0.464|
|[[:human genes:p:pik3r4|PIK3R4]]|0.462|
|[[:human genes:d:dnajc3|DNAJC3]]|0.462|
|[[:human genes:a:alg2|ALG2]]|0.461|
|[[:human genes:s:sec61g|SEC61G]]|0.459|
|[[:human genes:a:alg14|ALG14]]|0.458|
|[[:human genes:u:utp23|UTP23]]|0.457|
|[[:human genes:r:rbmx2|RBMX2]]|0.457|
|[[:human genes:r:rpe|RPE]]|0.456|
|[[:human genes:d:dohh|DOHH]]|0.455|
|[[:human genes:s:srprb|SRPRB]]|0.455|
|[[:human genes:s:snf8|SNF8]]|0.454|
|[[:human genes:s:srp19|SRP19]]|0.454|
|[[:human genes:d:derl2|DERL2]]|0.453|
|[[:human genes:s:sdha|SDHA]]|0.453|
|[[:human genes:h:haus8|HAUS8]]|0.453|
|[[:human genes:m:meaf6|MEAF6]]|0.452|
|[[:human genes:t:tmed10|TMED10]]|0.45|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.45|
|[[:human genes:t:tbca|TBCA]]|0.45|
|[[:human genes:e:eef1e1|EEF1E1]]|0.45|
|[[:human genes:w:wars|WARS]]|0.449|
|[[:human genes:v:vezt|VEZT]]|0.447|
|[[:human genes:m:mars|MARS]]|0.445|
|[[:human genes:v:vmp1|VMP1]]|0.443|
|[[:human genes:t:tcf4|TCF4]]|0.441|
|[[:human genes:a:alg6|ALG6]]|0.439|
|[[:human genes:p:pam16|PAM16]]|0.439|
|[[:human genes:a:atp5j|ATP5J]]|0.437|
|[[:human genes:r:rpn1|RPN1]]|0.436|
|[[:human genes:m:med23|MED23]]|0.436|
|[[:human genes:a:atrx|ATRX]]|0.435|
|[[:human genes:c:csnk2b|CSNK2B]]|0.435|
|[[:human genes:d:dnajb11|DNAJB11]]|0.433|
|[[:human genes:r:rbm14|RBM14]]|0.433|
|[[:human genes:c:cdipt|CDIPT]]|0.432|
|[[:human genes:p:pax5|PAX5]]|0.432|
|[[:human genes:n:nsmce2|NSMCE2]]|0.432|
|[[:human genes:t:thoc3|THOC3]]|0.43|
|[[:human genes:f:fnta|FNTA]]|0.429|
|[[:human genes:m:mllt1|MLLT1]]|0.429|
|[[:human genes:g:gtf3a|GTF3A]]|0.429|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.429|
|[[:human genes:m:med4|MED4]]|0.425|
|[[:human genes:e:eno1|ENO1]]|0.425|
|[[:human genes:m:mad2l1|MAD2L1]]|0.425|
|[[:human genes:e:eif3f|EIF3F]]|0.424|
|[[:human genes:s:spcs3|SPCS3]]|0.424|
|[[:human genes:e:exoc3|EXOC3]]|0.423|
|[[:human genes:t:thoc6|THOC6]]|0.421|
|[[:human genes:s:snapc5|SNAPC5]]|0.421|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.42|
|[[:human genes:t:txnl4b|TXNL4B]]|0.416|
|[[:human genes:s:seh1l|SEH1L]]|0.416|
|[[:human genes:b:bub3|BUB3]]|0.415|
|[[:human genes:t:tbp|TBP]]|0.413|
|[[:human genes:c:crcp|CRCP]]|0.412|
|[[:human genes:d:dolk|DOLK]]|0.411|
|[[:human genes:s:ssbp2|SSBP2]]|0.41|
|[[:human genes:d:dpf2|DPF2]]|0.409|
|[[:human genes:u:uba5|UBA5]]|0.409|
|[[:human genes:g:gtf3c5|GTF3C5]]|0.408|
|[[:human genes:w:wdr92|WDR92]]|0.407|
|[[:human genes:e:elac2|ELAC2]]|0.406|
|[[:human genes:s:spcs2|SPCS2]]|0.406|
|[[:human genes:n:naa20|NAA20]]|0.405|
|[[:human genes:u:ube2j1|UBE2J1]]|0.405|
|[[:human genes:m:mtor|MTOR]]|0.404|
|[[:human genes:t:tprkb|TPRKB]]|0.402|
|[[:human genes:f:fli1|FLI1]]|0.402|
|[[:human genes:d:ddost|DDOST]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 490
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTF3C2 Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>