======= GUK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GUK1
  * **<color #00a2e8>Official Name</color>**: guanylate kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2987|2987]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16774|Q16774]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GUK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GUK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139270|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for recycling GMP and indirectly, cGMP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Guanylate kin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dGMP metabolic process|
|dGDP biosynthetic process|
|GDP biosynthetic process|
|purine deoxyribonucleoside monophosphate metabolic process|
|purine deoxyribonucleoside diphosphate biosynthetic process|
|dGDP metabolic process|
|purine deoxyribonucleotide biosynthetic process|
|purine deoxyribonucleoside diphosphate metabolic process|
|deoxyribonucleoside diphosphate biosynthetic process|
|glycoprotein transport|
|dATP metabolic process|
|deoxyribonucleoside diphosphate metabolic process|
|purine nucleoside diphosphate biosynthetic process|
|purine ribonucleoside diphosphate biosynthetic process|
|ribonucleoside diphosphate biosynthetic process|
|GDP-mannose metabolic process|
|guanylate kinase activity|
|purine deoxyribonucleoside triphosphate metabolic process|
|nucleoside diphosphate biosynthetic process|
|GDP metabolic process|
|purine deoxyribonucleotide metabolic process|
|2-deoxyribonucleotide biosynthetic process|
|deoxyribose phosphate biosynthetic process|
|deoxyribonucleoside monophosphate metabolic process|
|guanosine-containing compound biosynthetic process|
|GMP metabolic process|
|deoxyribonucleotide biosynthetic process|
|deoxyribonucleoside triphosphate metabolic process|
|purine nucleoside biosynthetic process|
|purine ribonucleoside biosynthetic process|
|ribonucleoside biosynthetic process|
|nucleobase-containing small molecule interconversion|
|2-deoxyribonucleotide metabolic process|
|deoxyribose phosphate metabolic process|
|deoxyribonucleotide metabolic process|
|nucleotide-sugar metabolic process|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|nucleoside biosynthetic process|
|guanosine-containing compound metabolic process|
|glycosyl compound biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|purine ribonucleoside metabolic process|
|nucleotide phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|purine nucleoside diphosphate metabolic process|
|purine nucleoside metabolic process|
|ribonucleoside diphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|carbohydrate derivative transport|
|nucleoside monophosphate metabolic process|
|ribonucleoside metabolic process|
|nucleoside diphosphate metabolic process|
|nucleoside triphosphate metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|glycosyl compound metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.81|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.41|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 729/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|24/26|
|breast|31/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 372
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GUK1 Expression in NALM6 Cells: 6.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>