======= GYPB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GYPB
  * **<color #00a2e8>Official Name</color>**: glycophorin B (MNS blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2994|2994]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06028|P06028]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GYPB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GYPB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617923|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This protein is a minor sialoglycoprotein in erythrocyte membranes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glycophorin A|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leukocyte migration|
|cell migration|
|cell motility|
|localization of cell|
|locomotion|
|integral component of plasma membrane|
|movement of cell or subcellular component|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.96|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.89|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.78|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.72|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.71|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.7|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14411
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GYPB Expression in NALM6 Cells: -1.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>