======= GZMB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GZMB
  * **<color #00a2e8>Official Name</color>**: granzyme B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3002|3002]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10144|P10144]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GZMB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GZMB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123910|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Trypsin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|granzyme-mediated apoptotic signaling pathway|
|cytolysis|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|natural killer cell mediated cytotoxicity|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|natural killer cell mediated immunity|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|immunological synapse|
|leukocyte mediated cytotoxicity|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|positive regulation of establishment of protein localization to mitochondrion|
|serine-type peptidase activity|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|regulation of membrane permeability|
|cell killing|
|positive regulation of mitochondrion organization|
|positive regulation of protein localization to membrane|
|mitochondrial membrane organization|
|serine-type endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|regulation of protein localization to membrane|
|mitochondrial transport|
|lymphocyte mediated immunity|
|apoptotic signaling pathway|
|positive regulation of cellular protein localization|
|regulation of apoptotic signaling pathway|
|mitochondrion organization|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of establishment of protein localization|
|leukocyte mediated immunity|
|innate immune response|
|membrane organization|
|regulation of cellular localization|
|apoptotic process|
|defense response to other organism|
|positive regulation of transport|
|regulation of protein localization|
|programmed cell death|
|cell death|
|immune effector process|
|positive regulation of cellular component organization|
|mitochondrion|
|proteolysis|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.72|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.74|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.92|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.93|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.583|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4011
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GZMB Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>