======= H3F3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H3-3A
  * **<color #00a2e8>Official Name</color>**: H3.3 histone A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3020|3020]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P84243|P84243]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=H3F3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20H3F3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601128|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of chromosome condensation|
|telomeric heterochromatin assembly|
|pericentric heterochromatin assembly|
|regulation of chromosome condensation|
|regulation of centromere complex assembly|
|Barr body|
|heterochromatin assembly|
|chromatin silencing at rDNA|
|nuclear nucleosome|
|heterochromatin organization|
|nuclear chromosome|
|RNA polymerase II core promoter sequence-specific DNA binding|
|chromatin remodeling at centromere|
|embryo implantation|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|nucleosomal DNA binding|
|regulation of megakaryocyte differentiation|
|chromatin organization involved in negative regulation of transcription|
|chromatin silencing|
|nucleosome|
|chromatin organization involved in regulation of transcription|
|oogenesis|
|negative regulation of gene expression, epigenetic|
|multicellular organism growth|
|regulation of gene silencing by miRNA|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|telomere organization|
|nuclear chromosome, telomeric region|
|nucleosome assembly|
|osteoblast differentiation|
|regulation of gene silencing|
|female gamete generation|
|nucleus organization|
|chromatin assembly|
|negative regulation of chromosome organization|
|male gonad development|
|development of primary male sexual characteristics|
|single fertilization|
|spermatid development|
|gene silencing|
|chromatin assembly or disassembly|
|spermatid differentiation|
|nucleosome organization|
|male sex differentiation|
|chromatin remodeling|
|positive regulation of cell growth|
|fertilization|
|DNA packaging|
|female pregnancy|
|protein-DNA complex assembly|
|gonad development|
|multi-multicellular organism process|
|development of primary sexual characteristics|
|regulation of myeloid cell differentiation|
|regulation of gene expression, epigenetic|
|protein-DNA complex subunit organization|
|muscle cell differentiation|
|germ cell development|
|positive regulation of growth|
|ossification|
|sex differentiation|
|blood coagulation|
|coagulation|
|DNA conformation change|
|hemostasis|
|regulation of chromosome organization|
|cellular process involved in reproduction in multicellular organism|
|negative regulation of organelle organization|
|developmental growth|
|growth|
|regulation of cell growth|
|reproductive structure development|
|reproductive system development|
|regulation of protein complex assembly|
|regulation of hemopoiesis|
|muscle structure development|
|wound healing|
|protein heterodimerization activity|
|regulation of body fluid levels|
|spermatogenesis|
|cell population proliferation|
|male gamete generation|
|response to wounding|
|protein-containing complex|
|developmental process involved in reproduction|
|regulation of growth|
|gamete generation|
|chromatin organization|
|negative regulation of cellular component organization|
|brain development|
|head development|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|response to hormone|
|regulation of cellular component biogenesis|
|central nervous system development|
|multi-organism reproductive process|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|cell development|
|regulation of immune system process|
|negative regulation of gene expression|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gata3|GATA3]]|0.452|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.44|
|[[:human genes:m:med15|MED15]]|0.429|
|[[:human genes:o:ogfr|OGFR]]|0.419|
|[[:human genes:c:chd4|CHD4]]|0.41|
|[[:human genes:m:med14|MED14]]|0.404|
|[[:human genes:e:ep300|EP300]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 28/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1417
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='H3F3A Expression in NALM6 Cells: 8.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>