======= H6PD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H6PD
  * **<color #00a2e8>Official Name</color>**: hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9563|9563]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95479|O95479]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=H6PD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20H6PD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138090|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G6PD N|
|Glucosamine iso|
|G6PD C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glucose 1-dehydrogenase [NAD(P)] activity|
|glucose-6-phosphate dehydrogenase activity|
|6-phosphogluconolactonase activity|
|pentose-phosphate shunt|
|NADPH regeneration|
|glucose 6-phosphate metabolic process|
|NADP metabolic process|
|NADP binding|
|glucose metabolic process|
|hexose metabolic process|
|monosaccharide metabolic process|
|endoplasmic reticulum lumen|
|generation of precursor metabolites and energy|
|carbohydrate metabolic process|
|organophosphate metabolic process|
|oxidation-reduction process|
|carbohydrate derivative metabolic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5123
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='H6PD Expression in NALM6 Cells: 5.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>