======= HAS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HAS2
  * **<color #00a2e8>Official Name</color>**: hyaluronan synthase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3037|3037]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92819|Q92819]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HAS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HAS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601636|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Chitin synth 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extracellular polysaccharide biosynthetic process|
|positive regulation of monocyte aggregation|
|renal water absorption|
|regulation of monocyte aggregation|
|extracellular polysaccharide metabolic process|
|hyaluronan synthase activity|
|positive regulation of hyaluronan biosynthetic process|
|renal water transport|
|endocardial cushion to mesenchymal transition|
|atrioventricular canal development|
|hyaluronan biosynthetic process|
|regulation of hyaluronan biosynthetic process|
|regulation of extracellular matrix assembly|
|positive regulation of keratinocyte proliferation|
|positive regulation of keratinocyte migration|
|renal absorption|
|positive regulation of urine volume|
|regulation of keratinocyte migration|
|estrous cycle|
|cellular response to fluid shear stress|
|water transport|
|cellular response to platelet-derived growth factor stimulus|
|extracellular matrix assembly|
|response to platelet-derived growth factor|
|regulation of urine volume|
|fluid transport|
|cardiac epithelial to mesenchymal transition|
|plasma membrane raft|
|hyaluronan metabolic process|
|regulation of keratinocyte proliferation|
|response to fluid shear stress|
|renal water homeostasis|
|positive regulation of smooth muscle cell migration|
|positive regulation of substrate adhesion-dependent cell spreading|
|regulation of polysaccharide biosynthetic process|
|regulation of extracellular matrix organization|
|regulation of polysaccharide metabolic process|
|cellular polysaccharide biosynthetic process|
|polysaccharide biosynthetic process|
|regulation of substrate adhesion-dependent cell spreading|
|cellular carbohydrate biosynthetic process|
|regulation of smooth muscle cell migration|
|multicellular organismal water homeostasis|
|ovulation cycle|
|vasculogenesis|
|epithelial to mesenchymal transition|
|water homeostasis|
|cellular polysaccharide metabolic process|
|positive regulation of carbohydrate metabolic process|
|polysaccharide metabolic process|
|regulation of carbohydrate biosynthetic process|
|glycosaminoglycan biosynthetic process|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|renal system process|
|bone morphogenesis|
|positive regulation of cell-substrate adhesion|
|carbohydrate biosynthetic process|
|positive regulation of small molecule metabolic process|
|positive regulation of epithelial cell migration|
|positive regulation of cell morphogenesis involved in differentiation|
|glycosaminoglycan metabolic process|
|mesenchymal cell differentiation|
|aminoglycan metabolic process|
|cellular carbohydrate metabolic process|
|cellular response to interleukin-1|
|positive regulation of epithelial cell proliferation|
|response to interleukin-1|
|bone development|
|regulation of carbohydrate metabolic process|
|regulation of cell-substrate adhesion|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of epithelial cell migration|
|mesenchyme development|
|skeletal system morphogenesis|
|cellular response to tumor necrosis factor|
|heart morphogenesis|
|positive regulation of cell-cell adhesion|
|response to tumor necrosis factor|
|kidney development|
|rhythmic process|
|renal system development|
|regulation of leukocyte cell-cell adhesion|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|regulation of cell morphogenesis involved in differentiation|
|urogenital system development|
|multicellular organismal homeostasis|
|regulation of epithelial cell proliferation|
|extracellular matrix organization|
|extracellular structure organization|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|regulation of small molecule metabolic process|
|carbohydrate metabolic process|
|blood vessel development|
|regulation of cell morphogenesis|
|skeletal system development|
|regulation of body fluid levels|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of locomotion|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|tube morphogenesis|
|regulation of cell adhesion|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|circulatory system development|
|carboxylic acid metabolic process|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cell development|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|response to cytokine|
|chemical homeostasis|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of developmental process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of cell population proliferation|
|homeostatic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.84|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16030
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HAS2 Expression in NALM6 Cells: 0.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>