======= HBEGF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HBEGF
  * **<color #00a2e8>Official Name</color>**: heparin binding EGF like growth factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1839|1839]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99075|Q99075]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HBEGF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HBEGF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/126150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of elastin biosynthetic process|
|negative regulation of elastin biosynthetic process|
|wound healing, spreading of epidermal cells|
|positive regulation of keratinocyte migration|
|negative regulation of glycoprotein biosynthetic process|
|regulation of keratinocyte migration|
|negative regulation of glycoprotein metabolic process|
|wound healing, spreading of cells|
|epiboly involved in wound healing|
|epiboly|
|ERBB2 signaling pathway|
|epidermal growth factor receptor binding|
|clathrin-coated endocytic vesicle membrane|
|regulation of glycoprotein biosynthetic process|
|regulation of glycoprotein metabolic process|
|negative regulation of epidermal growth factor receptor signaling pathway|
|morphogenesis of an epithelial sheet|
|epidermal growth factor receptor signaling pathway|
|negative regulation of ERBB signaling pathway|
|clathrin-coated vesicle membrane|
|positive regulation of wound healing|
|positive regulation of response to wounding|
|endocytic vesicle membrane|
|ERBB signaling pathway|
|regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of smooth muscle cell proliferation|
|regulation of ERBB signaling pathway|
|regulation of smooth muscle cell proliferation|
|regulation of wound healing|
|positive regulation of epithelial cell migration|
|growth factor activity|
|positive regulation of cell growth|
|positive regulation of protein kinase B signaling|
|regulation of response to wounding|
|heparin binding|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cell chemotaxis|
|regulation of epithelial cell migration|
|regulation of protein kinase B signaling|
|regulation of heart contraction|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of growth|
|regulation of blood circulation|
|muscle organ development|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of cell growth|
|morphogenesis of an epithelium|
|muscle structure development|
|wound healing|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|tissue morphogenesis|
|response to wounding|
|regulation of system process|
|cell surface|
|regulation of growth|
|enzyme linked receptor protein signaling pathway|
|regulation of cell migration|
|membrane organization|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cell migration|
|protein phosphorylation|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|negative regulation of protein metabolic process|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9243
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HBEGF Expression in NALM6 Cells: 7.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>