======= HCN4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HCN4
  * **<color #00a2e8>Official Name</color>**: hyperpolarization activated cyclic nucleotide gated potassium channel 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10021|10021]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3Q4|Q9Y3Q4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HCN4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HCN4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605206|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510, ECO:0000269|PubMed:19165230, ECO:0000269|PubMed:20829353}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|cNMP binding|
|Ion trans|
|Ion trans N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|voltage-gated potassium channel activity involved in SA node cell action potential depolarization|
|HCN channel complex|
|membrane depolarization during SA node cell action potential|
|cellular response to cGMP|
|response to cGMP|
|regulation of cardiac muscle cell action potential involved in regulation of contraction|
|SA node cell to atrial cardiac muscle cell signaling|
|SA node cell action potential|
|SA node cell to atrial cardiac muscle cell communication|
|intracellular cAMP-activated cation channel activity|
|sodium ion import across plasma membrane|
|membrane depolarization during cardiac muscle cell action potential|
|voltage-gated sodium channel activity|
|cAMP binding|
|cell-cell signaling involved in cardiac conduction|
|regulation of cardiac muscle cell action potential|
|membrane depolarization during action potential|
|intrinsic component of plasma membrane|
|regulation of heart rate by cardiac conduction|
|regulation of cardiac muscle cell contraction|
|regulation of actin filament-based movement|
|potassium ion import across plasma membrane|
|regulation of membrane depolarization|
|cell communication involved in cardiac conduction|
|regulation of action potential|
|cardiac muscle cell action potential|
|membrane depolarization|
|cellular response to cAMP|
|voltage-gated potassium channel activity|
|inorganic cation import across plasma membrane|
|inorganic ion import across plasma membrane|
|regulation of cardiac muscle contraction|
|sodium ion transmembrane transport|
|regulation of striated muscle contraction|
|cardiac conduction|
|action potential|
|import across plasma membrane|
|regulation of heart rate|
|response to cAMP|
|multicellular organismal signaling|
|response to organophosphorus|
|response to purine-containing compound|
|sodium ion transport|
|potassium ion transmembrane transport|
|regulation of muscle contraction|
|potassium ion transport|
|regulation of muscle system process|
|regulation of heart contraction|
|muscle contraction|
|regulation of blood circulation|
|muscle system process|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|cellular response to organic cyclic compound|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|import into cell|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|ion homeostasis|
|cation transport|
|response to organic cyclic compound|
|ion transmembrane transport|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|chemical homeostasis|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.8|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14990
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HCN4 Expression in NALM6 Cells: -2.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>