======= HDAC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HDAC1
  * **<color #00a2e8>Official Name</color>**: histone deacetylase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3065|3065]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13547|Q13547]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HDAC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HDAC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601241|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. {ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hist deacetyl|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Krueppel-associated box domain binding|
|fungiform papilla formation|
|core promoter sequence-specific DNA binding|
|hair follicle placode formation|
|fungiform papilla morphogenesis|
|fungiform papilla development|
|Sin3-type complex|
|tongue morphogenesis|
|NAD-dependent histone deacetylase activity (H3-K14 specific)|
|ectodermal placode morphogenesis|
|ectodermal placode formation|
|protein deacetylase activity|
|histone H4 deacetylation|
|deacetylase activity|
|ectodermal placode development|
|methylation-dependent chromatin silencing|
|eyelid development in camera-type eye|
|positive regulation of receptor biosynthetic process|
|negative regulation by host of viral transcription|
|Sin3 complex|
|NuRD complex|
|negative regulation of androgen receptor signaling pathway|
|regulation of amyloid-beta clearance|
|negative regulation of myotube differentiation|
|histone H3 deacetylation|
|tongue development|
|positive regulation of oligodendrocyte differentiation|
|regulation of receptor biosynthetic process|
|regulation of androgen receptor signaling pathway|
|heterochromatin|
|negative regulation of viral transcription|
|histone deacetylase activity|
|beta-catenin-TCF complex assembly|
|NF-kappaB binding|
|activating transcription factor binding|
|RNA polymerase II core promoter sequence-specific DNA binding|
|RNA polymerase II repressing transcription factor binding|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|histone deacetylase complex|
|negative regulation of striated muscle cell differentiation|
|repressing transcription factor binding|
|regulation of oligodendrocyte differentiation|
|positive regulation of glial cell differentiation|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|nucleosomal DNA binding|
|promoter-specific chromatin binding|
|histone deacetylation|
|E-box binding|
|protein deacetylation|
|regulation of megakaryocyte differentiation|
|negative regulation of muscle cell differentiation|
|regulation of myotube differentiation|
|chromatin silencing|
|chromatin organization involved in negative regulation of transcription|
|protein deacylation|
|embryonic digit morphogenesis|
|RNA polymerase II transcription factor binding|
|circadian regulation of gene expression|
|macromolecule deacylation|
|regulation of viral transcription|
|p53 binding|
|regulation of glial cell differentiation|
|positive regulation of gliogenesis|
|chromatin organization involved in regulation of transcription|
|modification by host of symbiont morphology or physiology|
|hair follicle development|
|endoderm development|
|skin epidermis development|
|hair cycle process|
|molting cycle process|
|ATP-dependent chromatin remodeling|
|transcription regulatory region sequence-specific DNA binding|
|interaction with symbiont|
|regulation of intracellular steroid hormone receptor signaling pathway|
|hippocampus development|
|negative regulation of gene expression, epigenetic|
|odontogenesis of dentin-containing tooth|
|hair cycle|
|molting cycle|
|negative regulation of intrinsic apoptotic signaling pathway|
|negative regulation of viral process|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|regulation of striated muscle cell differentiation|
|protein N-terminus binding|
|limbic system development|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|histone deacetylase binding|
|chromatin|
|regulation of gliogenesis|
|odontogenesis|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|circadian rhythm|
|limb morphogenesis|
|appendage morphogenesis|
|gene silencing|
|regulation of muscle cell differentiation|
|modification of morphology or physiology of other organism|
|regulation of intrinsic apoptotic signaling pathway|
|chromatin remodeling|
|pallium development|
|negative regulation of canonical Wnt signaling pathway|
|limb development|
|appendage development|
|regulation of signal transduction by p53 class mediator|
|transcription factor complex|
|regulation of viral process|
|negative regulation of Wnt signaling pathway|
|negative regulation of multi-organism process|
|transcription regulatory region DNA binding|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of myeloid cell differentiation|
|negative regulation of apoptotic signaling pathway|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|transcription corepressor activity|
|sensory organ morphogenesis|
|telencephalon development|
|rhythmic process|
|regulation of canonical Wnt signaling pathway|
|blood coagulation|
|coagulation|
|hemostasis|
|camera-type eye development|
|epidermal cell differentiation|
|transcription factor binding|
|enzyme binding|
|eye development|
|visual system development|
|regulation of Wnt signaling pathway|
|histone modification|
|sensory system development|
|neuronal cell body|
|covalent chromatin modification|
|skin development|
|forebrain development|
|regulation of apoptotic signaling pathway|
|epidermis development|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|regulation of hemopoiesis|
|positive regulation of neurogenesis|
|wound healing|
|regulation of body fluid levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|negative regulation of intracellular signal transduction|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|embryonic morphogenesis|
|response to wounding|
|protein-containing complex|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|chromatin organization|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|brain development|
|regulation of multi-organism process|
|head development|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|neuron differentiation|
|chromosome organization|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.77|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.42|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.33|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.04|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.88|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.87|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.73|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.72|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.74|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.86|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.04|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.11|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.79|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mta2|MTA2]]|0.535|
|[[:human genes:h:hdac2|HDAC2]]|0.523|
|[[:human genes:m:mbd2|MBD2]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14376
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HDAC1 Expression in NALM6 Cells: 7.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>