======= HEXIM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HEXIM1
  * **<color #00a2e8>Official Name</color>**: HEXIM P-TEFb complex subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10614|10614]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94992|O94992]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HEXIM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HEXIM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607328|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|snRNA binding|
|7SK snRNA binding|
|cyclin-dependent protein serine/threonine kinase inhibitor activity|
|positive regulation of signal transduction by p53 class mediator|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of cyclin-dependent protein kinase activity|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|negative regulation of protein serine/threonine kinase activity|
|regulation of signal transduction by p53 class mediator|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|activation of innate immune response|
|negative regulation of transferase activity|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|regulation of innate immune response|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|regulation of response to biotic stimulus|
|heart development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|positive regulation of response to external stimulus|
|activation of immune response|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|defense response to other organism|
|regulation of transferase activity|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|positive regulation of signal transduction|
|regulation of immune system process|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-3.27|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.86|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.85|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.58|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.52|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.52|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.51|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.51|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.48|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.39|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.34|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.34|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.31|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.31|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.28|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.21|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.17|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.14|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.13|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.97|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.95|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.95|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.92|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.87|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.86|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.83|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.81|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.78|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.75|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.74|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.7|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.74|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.77|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.81|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.84|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.88|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.92|
|[[:results:exp453|B02 10μM R08 exp453]]|2|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.14|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.18|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.54|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.65|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.65|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.76|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.93|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|3.01|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|3.77|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|3.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:larp7|LARP7]]|0.633|
|[[:human genes:r:rbm26|RBM26]]|0.481|
|[[:human genes:p:prim1|PRIM1]]|0.445|
|[[:human genes:i:ing1|ING1]]|0.442|
|[[:human genes:m:mepce|MEPCE]]|0.437|
|[[:human genes:s:szt2|SZT2]]|0.426|
|[[:human genes:b:brms1|BRMS1]]|0.422|
|[[:human genes:n:nprl3|NPRL3]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17768
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HEXIM1 Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>