======= HEY2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HEY2
  * **<color #00a2e8>Official Name</color>**: hes related family bHLH transcription factor with YRPW motif 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23493|23493]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBP5|Q9UBP5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HEY2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HEY2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604674|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. {ECO:0000269|PubMed:10692439, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:16293227}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hairy orange|
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cardiac vascular smooth muscle cell differentiation|
|tricuspid valve formation|
|umbilical cord morphogenesis|
|umbilical cord development|
|endocardial cushion to mesenchymal transition involved in heart valve formation|
|negative regulation of transcription by transcription factor localization|
|cardiac vascular smooth muscle cell development|
|negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|
|regulation of cardiac vascular smooth muscle cell differentiation|
|ascending aorta morphogenesis|
|tricuspid valve morphogenesis|
|endocardial cushion to mesenchymal transition|
|negative regulation of transcription initiation from RNA polymerase II promoter|
|ascending aorta development|
|arterial endothelial cell differentiation|
|muscular septum morphogenesis|
|tricuspid valve development|
|negative regulation of DNA-templated transcription, initiation|
|pulmonary artery morphogenesis|
|cardiac vascular smooth muscle cell differentiation|
|negative regulation of vascular smooth muscle cell differentiation|
|regulation of inner ear auditory receptor cell differentiation|
|blood vessel endothelial cell differentiation|
|dorsal aorta morphogenesis|
|regulation of inner ear receptor cell differentiation|
|atrioventricular valve formation|
|regulation of mechanoreceptor differentiation|
|vascular smooth muscle cell development|
|dorsal aorta development|
|ventricular cardiac muscle cell development|
|Notch signaling involved in heart development|
|heart valve formation|
|heart trabecula formation|
|epithelial to mesenchymal transition involved in endocardial cushion formation|
|muscle hypertrophy in response to stress|
|regulation of vascular smooth muscle cell differentiation|
|cardiac muscle hypertrophy in response to stress|
|vascular smooth muscle cell differentiation|
|cardiac muscle adaptation|
|regulation of vasculogenesis|
|Sin3 complex|
|cardiac left ventricle morphogenesis|
|negative regulation of smooth muscle cell differentiation|
|atrial septum morphogenesis|
|coronary vasculature morphogenesis|
|ventricular cardiac muscle cell differentiation|
|ventricular trabecula myocardium morphogenesis|
|pulmonary valve morphogenesis|
|labyrinthine layer blood vessel development|
|cardiac right ventricle morphogenesis|
|endocardial cushion formation|
|negative regulation of cardiocyte differentiation|
|pulmonary valve development|
|atrial septum development|
|negative regulation of transcription regulatory region DNA binding|
|negative regulation of cardiac muscle cell apoptotic process|
|trabecula formation|
|atrioventricular valve morphogenesis|
|cell surface receptor signaling pathway involved in heart development|
|positive regulation of heart rate|
|negative regulation of striated muscle cell apoptotic process|
|positive regulation of cardiac muscle cell proliferation|
|atrioventricular valve development|
|regulation of transcription initiation from RNA polymerase II promoter|
|striated muscle adaptation|
|negative regulation of biomineralization|
|cardiac epithelial to mesenchymal transition|
|negative regulation of biomineral tissue development|
|aorta morphogenesis|
|aortic valve morphogenesis|
|cardiac muscle hypertrophy|
|cardiac atrium morphogenesis|
|placenta blood vessel development|
|striated muscle hypertrophy|
|regulation of smooth muscle cell differentiation|
|heart trabecula morphogenesis|
|muscle hypertrophy|
|muscle adaptation|
|smooth muscle cell differentiation|
|aortic valve development|
|positive regulation of cardiac muscle tissue growth|
|endocardial cushion morphogenesis|
|cardiac atrium development|
|regulation of DNA-templated transcription, initiation|
|negative regulation of muscle cell apoptotic process|
|semi-lunar valve development|
|positive regulation of heart growth|
|regulation of cardiac muscle cell apoptotic process|
|positive regulation of heart contraction|
|regulation of striated muscle cell apoptotic process|
|regulation of cardiac muscle cell proliferation|
|ventricular septum morphogenesis|
|negative regulation of Notch signaling pathway|
|endocardial cushion development|
|positive regulation of cardiac muscle tissue development|
|trabecula morphogenesis|
|coronary vasculature development|
|labyrinthine layer development|
|positive regulation of organ growth|
|ventricular cardiac muscle tissue morphogenesis|
|anterior/posterior axis specification|
|regulation of cardiocyte differentiation|
|mesenchyme morphogenesis|
|aorta development|
|cochlea development|
|heart valve morphogenesis|
|regulation of transcription regulatory region DNA binding|
|RNA polymerase II activating transcription factor binding|
|negative regulation of muscle cell differentiation|
|negative regulation of DNA binding|
|ventricular cardiac muscle tissue development|
|transcriptional repressor complex|
|regulation of cardiac muscle tissue growth|
|cardiac muscle cell development|
|regulation of epidermal cell differentiation|
|artery morphogenesis|
|heart valve development|
|regulation of heart growth|
|cardiac cell development|
|cardiac muscle tissue morphogenesis|
|vasculogenesis|
|regulation of muscle cell apoptotic process|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of blood circulation|
|positive regulation of muscle tissue development|
|epithelial to mesenchymal transition|
|ventricular septum development|
|cardiac ventricle morphogenesis|
|cardiac septum morphogenesis|
|outflow tract morphogenesis|
|regulation of cardiac muscle tissue development|
|muscle tissue morphogenesis|
|endothelial cell differentiation|
|mesenchymal cell development|
|axis specification|
|artery development|
|regulation of epidermis development|
|muscle organ morphogenesis|
|embryonic placenta development|
|cardiac muscle cell differentiation|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|regulation of organ growth|
|endothelium development|
|regulation of heart rate|
|regulation of Notch signaling pathway|
|cardiac septum development|
|histone deacetylase binding|
|cardiocyte differentiation|
|negative regulation of vasculature development|
|Notch signaling pathway|
|regulation of DNA binding|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of striated muscle tissue development|
|striated muscle cell development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of epithelial cell differentiation|
|muscle cell development|
|placenta development|
|regulation of muscle cell differentiation|
|mesenchymal cell differentiation|
|cardiac muscle tissue development|
|negative regulation of binding|
|cardiac chamber development|
|positive regulation of developmental growth|
|inner ear development|
|striated muscle cell differentiation|
|protein-DNA complex assembly|
|anterior/posterior pattern specification|
|mesenchyme development|
|ear development|
|protein-DNA complex subunit organization|
|regulation of heart contraction|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|muscle cell differentiation|
|cell fate commitment|
|heart morphogenesis|
|positive regulation of growth|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of vasculature development|
|regulation of developmental growth|
|transcription factor binding|
|regionalization|
|in utero embryonic development|
|regulation of binding|
|blood vessel morphogenesis|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|pattern specification process|
|muscle structure development|
|blood vessel development|
|protein heterodimerization activity|
|vasculature development|
|cardiovascular system development|
|heart development|
|sensory organ development|
|tissue morphogenesis|
|regulation of system process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|regulation of growth|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|cellular protein-containing complex assembly|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|negative regulation of cell death|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17867
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HEY2 Expression in NALM6 Cells: -0.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>