======= HFE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HFE
  * **<color #00a2e8>Official Name</color>**: homeostatic iron regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3077|3077]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q30201|Q30201]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HFE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HFE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613609|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1-set|
|MHC I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to iron ion starvation|
|negative regulation of T cell antigen processing and presentation|
|regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I|
|iron ion import across plasma membrane|
|negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I|
|regulation of antigen processing and presentation of peptide antigen via MHC class I|
|regulation of T cell antigen processing and presentation|
|negative regulation of antigen processing and presentation of peptide antigen via MHC class I|
|positive regulation of ferrous iron binding|
|regulation of transferrin receptor binding|
|positive regulation of transferrin receptor binding|
|regulation of ferrous iron binding|
|terminal web|
|response to iron ion starvation|
|negative regulation of antigen processing and presentation of peptide antigen|
|iron import into cell|
|negative regulation of CD8-positive, alpha-beta T cell activation|
|regulation of antigen processing and presentation of peptide antigen|
|regulation of iron ion transport|
|transferrin receptor binding|
|HFE-transferrin receptor complex|
|beta-2-microglobulin binding|
|multicellular organismal iron ion homeostasis|
|negative regulation of antigen processing and presentation|
|negative regulation of T cell cytokine production|
|positive regulation of receptor binding|
|MHC class I protein complex|
|cellular response to iron ion|
|negative regulation of receptor binding|
|co-receptor binding|
|basal part of cell|
|iron ion transmembrane transport|
|regulation of CD8-positive, alpha-beta T cell activation|
|negative regulation of T cell mediated immunity|
|regulation of antigen processing and presentation|
|regulation of receptor binding|
|negative regulation of cytokine production involved in immune response|
|liver regeneration|
|regulation of T cell cytokine production|
|response to iron ion|
|peptide antigen binding|
|positive regulation of signaling receptor activity|
|negative regulation of production of molecular mediator of immune response|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|transferrin transport|
|regulation of protein localization to cell surface|
|negative regulation of alpha-beta T cell activation|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|acute-phase response|
|negative regulation of adaptive immune response|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|negative regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of leukocyte mediated immunity|
|positive regulation of receptor-mediated endocytosis|
|negative regulation of proteasomal protein catabolic process|
|negative regulation of signaling receptor activity|
|hormone biosynthetic process|
|regulation of pathway-restricted SMAD protein phosphorylation|
|cellular iron ion homeostasis|
|acute inflammatory response|
|regulation of T cell mediated immunity|
|apical part of cell|
|iron ion transport|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|animal organ regeneration|
|inorganic cation import across plasma membrane|
|inorganic ion import across plasma membrane|
|iron ion homeostasis|
|regulation of cytokine production involved in immune response|
|negative regulation of cellular protein catabolic process|
|BMP signaling pathway|
|regulation of alpha-beta T cell activation|
|positive regulation of protein binding|
|positive regulation of peptide hormone secretion|
|import across plasma membrane|
|antigen processing and presentation of peptide antigen via MHC class I|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|negative regulation of protein binding|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|cellular transition metal ion homeostasis|
|negative regulation of T cell activation|
|recycling endosome|
|negative regulation of immune effector process|
|transition metal ion transport|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|liver development|
|positive regulation of hormone secretion|
|hepaticobiliary system development|
|transition metal ion homeostasis|
|negative regulation of protein catabolic process|
|regulation of production of molecular mediator of immune response|
|negative regulation of lymphocyte activation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|cellular response to starvation|
|regulation of ubiquitin-dependent protein catabolic process|
|regeneration|
|regulation of adaptive immune response|
|negative regulation of binding|
|regulation of signaling receptor activity|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|positive regulation of binding|
|female pregnancy|
|regulation of proteasomal protein catabolic process|
|antigen processing and presentation of peptide antigen|
|cellular response to metal ion|
|response to starvation|
|negative regulation of cell activation|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|hormone metabolic process|
|regulation of leukocyte mediated immunity|
|regulation of endocytosis|
|regulation of peptide hormone secretion|
|multi-multicellular organism process|
|regulation of proteolysis involved in cellular protein catabolic process|
|antigen processing and presentation|
|regulation of protein binding|
|cellular response to inorganic substance|
|cellular response to nutrient levels|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|cytoplasmic vesicle|
|early endosome|
|cellular response to extracellular stimulus|
|regulation of hormone secretion|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|positive regulation of peptide secretion|
|regulation of leukocyte cell-cell adhesion|
|negative regulation of catabolic process|
|regulation of T cell activation|
|multicellular organismal homeostasis|
|cellular response to external stimulus|
|signaling receptor binding|
|negative regulation of proteolysis|
|response to metal ion|
|regulation of binding|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|gland development|
|positive regulation of secretion|
|negative regulation of immune system process|
|regulation of immune effector process|
|regulation of peptide secretion|
|response to nutrient levels|
|inflammatory response|
|cellular response to growth factor stimulus|
|regulation of lymphocyte activation|
|response to growth factor|
|response to extracellular stimulus|
|response to inorganic substance|
|regulation of hormone levels|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of leukocyte activation|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|regulation of cell activation|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|import into cell|
|regulation of cell adhesion|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|regulation of proteolysis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|regulation of cellular catabolic process|
|cellular homeostasis|
|regulation of cellular localization|
|ion transmembrane transport|
|positive regulation of transport|
|multi-organism reproductive process|
|regulation of catabolic process|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|transmembrane transport|
|defense response|
|ion transport|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17174
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HFE Expression in NALM6 Cells: 3.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>