======= HHEX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HHEX
  * **<color #00a2e8>Official Name</color>**: hematopoietically expressed homeobox
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3087|3087]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q03014|Q03014]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HHEX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HHEX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604420|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of transcription by transcription factor localization|
|eukaryotic initiation factor 4E binding|
|negative regulation of transcription by competitive promoter binding|
|negative regulation of vascular endothelial growth factor receptor signaling pathway|
|DNA binding, bending|
|poly(A)+ mRNA export from nucleus|
|TBP-class protein binding|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of cyclin-dependent protein kinase activity|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|repressing transcription factor binding|
|protein-DNA complex|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|B cell differentiation|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|negative regulation of vasculature development|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of cellular response to growth factor stimulus|
|protein export from nucleus|
|B cell activation|
|mRNA transport|
|nuclear export|
|protein localization to nucleus|
|positive regulation of Wnt signaling pathway|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|anterior/posterior pattern specification|
|RNA localization|
|transcription regulatory region DNA binding|
|regulation of leukocyte proliferation|
|negative regulation of protein kinase activity|
|lymphocyte differentiation|
|nucleobase-containing compound transport|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|negative regulation of kinase activity|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of cellular response to growth factor stimulus|
|negative regulation of transferase activity|
|regulation of angiogenesis|
|DNA conformation change|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of vasculature development|
|leukocyte differentiation|
|transcription factor binding|
|regionalization|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|lymphocyte activation|
|response to peptide hormone|
|negative regulation of protein phosphorylation|
|sequence-specific DNA binding|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|pattern specification process|
|negative regulation of phosphorylation|
|response to peptide|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of protein serine/threonine kinase activity|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|response to wounding|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|immune system development|
|protein localization to organelle|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|protein homodimerization activity|
|response to hormone|
|leukocyte activation|
|negative regulation of developmental process|
|regulation of transferase activity|
|intracellular protein transport|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|cell activation|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.85|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.78|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.75|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.83|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.83|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.02|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.04|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.26|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.56|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.538|
|[[:human genes:m:mllt1|MLLT1]]|0.51|
|[[:human genes:t:trim28|TRIM28]]|0.491|
|[[:human genes:o:otud5|OTUD5]]|0.48|
|[[:human genes:m:meaf6|MEAF6]]|0.467|
|[[:human genes:t:thoc6|THOC6]]|0.454|
|[[:human genes:i:id3|ID3]]|0.449|
|[[:human genes:n:nsd1|NSD1]]|0.447|
|[[:human genes:u:ube2l3|UBE2L3]]|0.446|
|[[:human genes:c:ccdc101|CCDC101]]|0.44|
|[[:human genes:r:rptor|RPTOR]]|0.434|
|[[:human genes:u:usp22|USP22]]|0.434|
|[[:human genes:z:znf592|ZNF592]]|0.431|
|[[:human genes:m:mtor|MTOR]]|0.429|
|[[:human genes:u:ubr5|UBR5]]|0.428|
|[[:human genes:t:tle4|TLE4]]|0.426|
|[[:human genes:f:fbxo11|FBXO11]]|0.424|
|[[:human genes:b:brpf1|BRPF1]]|0.424|
|[[:human genes:n:nxt1|NXT1]]|0.423|
|[[:human genes:c:csnk2b|CSNK2B]]|0.417|
|[[:human genes:v:vcpip1|VCPIP1]]|0.416|
|[[:human genes:a:atf7ip|ATF7IP]]|0.414|
|[[:human genes:m:med13l|MED13L]]|0.409|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4158
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HHEX Expression in NALM6 Cells: 4.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>