======= HIBCH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HIBCH
  * **<color #00a2e8>Official Name</color>**: 3-hydroxyisobutyryl-CoA hydrolase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26275|26275]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6NVY1|Q6NVY1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIBCH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIBCH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610690|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the enzyme responsible for hydrolysis of both HIBYL-CoA and beta-hydroxypropionyl-CoA. Mutations in this gene have been associated with 3-hyroxyisobutyryl-CoA hydrolase deficiency. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000269|PubMed:8824301}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ECH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-hydroxyisobutyryl-CoA hydrolase activity|
|valine catabolic process|
|valine metabolic process|
|branched-chain amino acid metabolic process|
|branched-chain amino acid catabolic process|
|fatty acid beta-oxidation|
|fatty acid oxidation|
|lipid oxidation|
|fatty acid catabolic process|
|alpha-amino acid catabolic process|
|monocarboxylic acid catabolic process|
|cellular amino acid catabolic process|
|cellular lipid catabolic process|
|lipid modification|
|alpha-amino acid metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|lipid catabolic process|
|cellular amino acid metabolic process|
|fatty acid metabolic process|
|mitochondrial matrix|
|small molecule catabolic process|
|monocarboxylic acid metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|lipid metabolic process|
|mitochondrion|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.81|
|[[:results:exp274|Citral 50μM R06 exp274]]|3.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13314
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIBCH Expression in NALM6 Cells: 4.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>