======= HIF1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HIF1A
  * **<color #00a2e8>Official Name</color>**: hypoxia inducible factor 1 subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3091|3091]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16665|Q16665]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIF1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIF1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603348|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia. {ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:9887100}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAS|
|HIF-1|
|HIF-1a CTAD|
|PAS 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of chemokine-mediated signaling pathway|
|vascular endothelial growth factor production|
|neural fold elevation formation|
|B-1 B cell homeostasis|
|epithelial cell differentiation involved in mammary gland alveolus development|
|intestinal epithelial cell maturation|
|hypoxia-inducible factor-1alpha signaling pathway|
|negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|
|hemoglobin biosynthetic process|
|elastin metabolic process|
|connective tissue replacement involved in inflammatory response wound healing|
|connective tissue replacement|
|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|wound healing involved in inflammatory response|
|neural fold formation|
|inflammatory response to wounding|
|oxygen homeostasis|
|columnar/cuboidal epithelial cell maturation|
|negative regulation of thymocyte apoptotic process|
|regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|
|regulation of transforming growth factor beta2 production|
|regulation of aerobic respiration|
|iris morphogenesis|
|regulation of chemokine-mediated signaling pathway|
|gas homeostasis|
|negative regulation of mesenchymal cell apoptotic process|
|hemoglobin metabolic process|
|positive regulation of hormone biosynthetic process|
|intestinal epithelial cell development|
|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|
|regulation of thymocyte apoptotic process|
|regulation of mesenchymal cell apoptotic process|
|lactate metabolic process|
|axonal transport of mitochondrion|
|positive regulation of receptor biosynthetic process|
|positive regulation of hormone metabolic process|
|positive regulation of vascular endothelial growth factor receptor signaling pathway|
|epithelial cell maturation|
|retina vasculature development in camera-type eye|
|mammary gland epithelial cell differentiation|
|mammary gland alveolus development|
|morphogenesis of an epithelial fold|
|negative regulation of T cell apoptotic process|
|mammary gland lobule development|
|negative regulation of bone mineralization|
|mRNA transcription by RNA polymerase II|
|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|positive regulation of autophagy of mitochondrion|
|intestinal epithelial cell differentiation|
|embryonic hemopoiesis|
|negative regulation of oxidative stress-induced neuron death|
|positive regulation of nitric-oxide synthase activity|
|mitochondrion transport along microtubule|
|muscle cell cellular homeostasis|
|establishment of mitochondrion localization, microtubule-mediated|
|positive regulation of neuroblast proliferation|
|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|
|positive regulation of glycolytic process|
|regulation of receptor biosynthetic process|
|response to muscle activity|
|B cell homeostasis|
|mRNA transcription|
|establishment of mitochondrion localization|
|regulation of oxidative stress-induced neuron death|
|nuclear hormone receptor binding|
|positive regulation of monooxygenase activity|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|regulation of hormone biosynthetic process|
|negative regulation of lymphocyte apoptotic process|
|negative regulation of biomineral tissue development|
|positive regulation of vascular endothelial growth factor production|
|negative regulation of biomineralization|
|histone acetyltransferase binding|
|regulation of cellular respiration|
|dopaminergic neuron differentiation|
|positive regulation of erythrocyte differentiation|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|regulation of neuroblast proliferation|
|regulation of vascular endothelial growth factor production|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|response to iron ion|
|regulation of T cell apoptotic process|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of transforming growth factor beta production|
|regulation of hormone metabolic process|
|positive regulation of stem cell proliferation|
|Hsp90 protein binding|
|regulation of autophagy of mitochondrion|
|regulation of pri-miRNA transcription by RNA polymerase II|
|regulation of nitric-oxide synthase activity|
|positive regulation of ATP metabolic process|
|positive regulation of nucleotide metabolic process|
|positive regulation of purine nucleotide metabolic process|
|negative regulation of oxidative stress-induced cell death|
|lactation|
|negative regulation of cellular response to oxidative stress|
|regulation of erythrocyte differentiation|
|negative regulation of leukocyte apoptotic process|
|mitochondrion localization|
|negative regulation of response to oxidative stress|
|visual learning|
|digestive tract morphogenesis|
|columnar/cuboidal epithelial cell development|
|negative regulation of TOR signaling|
|positive regulation of cytokine-mediated signaling pathway|
|E-box binding|
|regulation of lymphocyte apoptotic process|
|positive regulation of neural precursor cell proliferation|
|visual behavior|
|positive regulation of oxidoreductase activity|
|lymphocyte homeostasis|
|negative regulation of reactive oxygen species metabolic process|
|regulation of monooxygenase activity|
|positive regulation of blood vessel endothelial cell migration|
|neural crest cell migration|
|axonal transport|
|positive regulation of chemokine production|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|axon cytoplasm|
|positive regulation of response to cytokine stimulus|
|mammary gland epithelium development|
|heart looping|
|cellular iron ion homeostasis|
|regulation of oxidative stress-induced cell death|
|regulation of stem cell proliferation|
|response to activity|
|collagen metabolic process|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|axo-dendritic transport|
|p53 binding|
|positive regulation of macroautophagy|
|leukocyte homeostasis|
|epithelial to mesenchymal transition|
|RNA polymerase II transcription factor complex|
|positive regulation of insulin secretion|
|outflow tract morphogenesis|
|body fluid secretion|
|cardiac ventricle morphogenesis|
|negative regulation of ossification|
|regulation of bone mineralization|
|regulation of cellular response to oxidative stress|
|embryonic heart tube development|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|associative learning|
|regulation of chemokine production|
|neural crest cell development|
|positive regulation of carbohydrate metabolic process|
|regulation of glycolytic process|
|organelle transport along microtubule|
|iron ion homeostasis|
|regulation of leukocyte apoptotic process|
|mesenchymal cell development|
|stem cell development|
|regulation of response to oxidative stress|
|embryonic placenta development|
|regulation of neural precursor cell proliferation|
|regulation of carbohydrate catabolic process|
|neural crest cell differentiation|
|regulation of blood vessel endothelial cell migration|
|positive regulation of myeloid cell differentiation|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|positive regulation of endothelial cell proliferation|
|regulation of oxidoreductase activity|
|negative regulation of intrinsic apoptotic signaling pathway|
|columnar/cuboidal epithelial cell differentiation|
|positive regulation of peptide hormone secretion|
|primary neural tube formation|
|positive regulation of endothelial cell migration|
|motile cilium|
|tissue remodeling|
|regulation of TOR signaling|
|neural tube formation|
|cellular transition metal ion homeostasis|
|histone deacetylase binding|
|camera-type eye morphogenesis|
|positive regulation of mitochondrion organization|
|regulation of purine nucleotide metabolic process|
|cerebral cortex development|
|determination of left/right symmetry|
|regulation of nucleotide metabolic process|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of ATP metabolic process|
|positive regulation of autophagy|
|embryonic epithelial tube formation|
|determination of bilateral symmetry|
|specification of symmetry|
|regulation of DNA-templated transcription in response to stress|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|mammary gland development|
|positive regulation of hormone secretion|
|regulation of endothelial cell proliferation|
|transition metal ion homeostasis|
|digestive tract development|
|epithelial tube formation|
|anatomical structure maturation|
|positive regulation of small molecule metabolic process|
|retina development in camera-type eye|
|positive regulation of epithelial cell migration|
|digestive system development|
|morphogenesis of embryonic epithelium|
|negative regulation of neuron apoptotic process|
|learning|
|tube formation|
|eye morphogenesis|
|cytokine production|
|placenta development|
|mesenchymal cell differentiation|
|transport along microtubule|
|cell maturation|
|stem cell differentiation|
|regulation of endothelial cell migration|
|regulation of generation of precursor metabolites and energy|
|neural tube development|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of angiogenesis|
|cardiac chamber development|
|cartilage development|
|ameboidal-type cell migration|
|regulation of macroautophagy|
|pallium development|
|cellular response to interleukin-1|
|regulation of response to cytokine stimulus|
|cytoskeleton-dependent intracellular transport|
|regulation of insulin secretion|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|microtubule-based transport|
|positive regulation of vasculature development|
|glucose homeostasis|
|carbohydrate homeostasis|
|cellular response to hypoxia|
|positive regulation of hemopoiesis|
|positive regulation of epithelial cell proliferation|
|regulation of ossification|
|epithelial cell development|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|homeostasis of number of cells|
|regulation of carbohydrate metabolic process|
|transcription factor complex|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|regulation of peptide hormone secretion|
|cellular response to oxygen levels|
|regulation of epithelial cell migration|
|mesenchyme development|
|connective tissue development|
|regulation of myeloid cell differentiation|
|negative regulation of apoptotic signaling pathway|
|nuclear chromatin|
|cellular response to oxidative stress|
|developmental maturation|
|negative regulation of growth|
|protein domain specific binding|
|heart morphogenesis|
|sensory organ morphogenesis|
|telencephalon development|
|learning or memory|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|microtubule-based movement|
|regulation of cellular response to growth factor stimulus|
|protein deubiquitination|
|nuclear body|
|regulation of angiogenesis|
|embryonic organ morphogenesis|
|positive regulation of peptide secretion|
|ubiquitin protein ligase binding|
|protein modification by small protein removal|
|cognition|
|response to light stimulus|
|epithelial tube morphogenesis|
|regulation of neuron death|
|camera-type eye development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|angiogenesis|
|regulation of vasculature development|
|regulation of autophagy|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|anatomical structure homeostasis|
|response to hypoxia|
|enzyme binding|
|response to decreased oxygen levels|
|eye development|
|visual system development|
|post-translational protein modification|
|establishment of organelle localization|
|positive regulation of cellular catabolic process|
|sensory system development|
|response to metal ion|
|in utero embryonic development|
|response to oxygen levels|
|glycoprotein metabolic process|
|forebrain development|
|response to oxidative stress|
|regulation of apoptotic signaling pathway|
|nuclear speck|
|positive regulation of secretion by cell|
|blood vessel morphogenesis|
|gland development|
|sequence-specific DNA binding|
|reproductive structure development|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|reproductive system development|
|positive regulation of catabolic process|
|morphogenesis of an epithelium|
|embryonic organ development|
|positive regulation of secretion|
|pattern specification process|
|response to radiation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|organic hydroxy compound metabolic process|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|wound healing|
|transcription by RNA polymerase II|
|blood vessel development|
|protein heterodimerization activity|
|regulation of peptide secretion|
|skeletal system development|
|regulation of body fluid levels|
|inflammatory response|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|monocarboxylic acid metabolic process|
|response to inorganic substance|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|sensory organ development|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|hemopoiesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|behavior|
|response to wounding|
|organelle localization|
|protein-containing complex|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|metal ion homeostasis|
|chordate embryonic development|
|cellular cation homeostasis|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|cellular ion homeostasis|
|immune system development|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of growth|
|microtubule-based process|
|cytokine-mediated signaling pathway|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|protein ubiquitination|
|mRNA metabolic process|
|regulation of cytokine production|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|brain development|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|protein modification by small protein conjugation|
|head development|
|ion homeostasis|
|regulation of secretion|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|tube development|
|regulation of cell migration|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of cellular component movement|
|negative regulation of cell death|
|regulation of catabolic process|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|neuron differentiation|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|chemical homeostasis|
|epithelium development|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|proteolysis|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|locomotion|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of response to stress|
|intracellular transport|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.84|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.13|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.33|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|6.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:arnt|ARNT]]|0.524|
|[[:human genes:r:rrm1|RRM1]]|0.489|
|[[:human genes:n:nit2|NIT2]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10527
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIF1A Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>