======= HIPK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HIPK1
  * **<color #00a2e8>Official Name</color>**: homeodomain interacting protein kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=204851|204851]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86Z02|Q86Z02]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIPK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIPK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608003|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lens induction in camera-type eye|
|embryonic retina morphogenesis in camera-type eye|
|endothelial cell apoptotic process|
|iris morphogenesis|
|definitive hemopoiesis|
|retina layer formation|
|lens morphogenesis in camera-type eye|
|embryonic camera-type eye morphogenesis|
|developmental induction|
|epithelial cell apoptotic process|
|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|embryonic eye morphogenesis|
|adherens junction assembly|
|embryonic camera-type eye development|
|retina morphogenesis in camera-type eye|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|neural retina development|
|regulation of tumor necrosis factor-mediated signaling pathway|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|smoothened signaling pathway|
|lens development in camera-type eye|
|peptidyl-threonine phosphorylation|
|adherens junction organization|
|protein tyrosine kinase activity|
|peptidyl-threonine modification|
|extrinsic apoptotic signaling pathway|
|PML body|
|camera-type eye morphogenesis|
|signal transduction by p53 class mediator|
|retina development in camera-type eye|
|eye morphogenesis|
|intrinsic apoptotic signaling pathway|
|positive regulation of angiogenesis|
|regulation of cytokine-mediated signaling pathway|
|cell junction assembly|
|peptidyl-serine phosphorylation|
|regulation of response to cytokine stimulus|
|regulation of signal transduction by p53 class mediator|
|positive regulation of vasculature development|
|peptidyl-serine modification|
|cell junction organization|
|anterior/posterior pattern specification|
|sensory organ morphogenesis|
|apoptotic signaling pathway|
|regulation of angiogenesis|
|embryonic organ morphogenesis|
|camera-type eye development|
|regulation of vasculature development|
|regionalization|
|eye development|
|visual system development|
|protein serine/threonine kinase activity|
|sensory system development|
|nuclear speck|
|embryonic organ development|
|pattern specification process|
|centrosome|
|sensory organ development|
|hemopoiesis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|cellular response to DNA damage stimulus|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|apoptotic process|
|animal organ morphogenesis|
|protein phosphorylation|
|embryo development|
|neuron differentiation|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|phosphorylation|
|positive regulation of developmental process|
|ATP binding|
|generation of neurons|
|regulation of cell population proliferation|
|neurogenesis|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15788
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIPK1 Expression in NALM6 Cells: 7.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>