======= HIST1H4A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H4C1
  * **<color #00a2e8>Official Name</color>**: H4 clustered histone 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8359|8359]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62805|P62805]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIST1H4A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIST1H4A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602822|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of megakaryocyte differentiation|
|DNA replication-dependent nucleosome organization|
|DNA replication-dependent nucleosome assembly|
|chromatin silencing at rDNA|
|nuclear nucleosome|
|telomere capping|
|nuclear chromosome|
|CENP-A containing chromatin organization|
|CENP-A containing nucleosome assembly|
|protein heterotetramerization|
|chromatin remodeling at centromere|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|histone exchange|
|regulation of megakaryocyte differentiation|
|double-strand break repair via nonhomologous end joining|
|chromatin silencing|
|chromatin organization involved in negative regulation of transcription|
|non-recombinational repair|
|nucleosome|
|chromatin organization involved in regulation of transcription|
|ATP-dependent chromatin remodeling|
|negative regulation of myeloid cell differentiation|
|negative regulation of gene expression, epigenetic|
|regulation of gene silencing by miRNA|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|telomere maintenance|
|telomere organization|
|protein heterooligomerization|
|nuclear chromosome, telomeric region|
|nucleosome assembly|
|regulation of gene silencing|
|chromatin assembly|
|negative regulation of hemopoiesis|
|protein tetramerization|
|gene silencing|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|DNA packaging|
|double-strand break repair|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|regulation of myeloid cell differentiation|
|regulation of gene expression, epigenetic|
|protein-DNA complex subunit organization|
|protein domain specific binding|
|DNA conformation change|
|anatomical structure homeostasis|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|protein heterodimerization activity|
|DNA repair|
|protein complex oligomerization|
|protein-containing complex|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|negative regulation of cell differentiation|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|negative regulation of developmental process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|extracellular region|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.86|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3439
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIST1H4A Expression in NALM6 Cells: -1.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>