======= HIST2H2BF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H2BC18
  * **<color #00a2e8>Official Name</color>**: H2B clustered histone 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=440689|440689]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5QNW6|Q5QNW6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HIST2H2BF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HIST2H2BF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Histone|
|CBFD NFYB HMF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleosome|
|nucleosome assembly|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|DNA packaging|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|DNA conformation change|
|protein heterodimerization activity|
|chromatin organization|
|molecular function|
|cellular protein-containing complex assembly|
|chromosome organization|
|DNA binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.57|
|[[:human genes:p:psmd3|PSMD3]]|0.535|
|[[:human genes:o:orc6|ORC6]]|0.506|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.501|
|[[:human genes:c:c14orf93|C14orf93]]|0.498|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.495|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.494|
|[[:human genes:s:supt6h|SUPT6H]]|0.492|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.484|
|[[:human genes:c:cbwd3|CBWD3]]|0.481|
|[[:human genes:p:psmc1|PSMC1]]|0.48|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.479|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.479|
|[[:human genes:t:tfip11|TFIP11]]|0.478|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.478|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.478|
|[[:human genes:c:copg1|COPG1]]|0.473|
|[[:human genes:s:ssh2|SSH2]]|0.471|
|[[:human genes:c:cbwd5|CBWD5]]|0.468|
|[[:human genes:c:ccna2|CCNA2]]|0.468|
|[[:human genes:s:snrpa1|SNRPA1]]|0.467|
|[[:human genes:u:upf1|UPF1]]|0.462|
|[[:human genes:p:pwp2|PWP2]]|0.462|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.458|
|[[:human genes:a:arcn1|ARCN1]]|0.457|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.457|
|[[:human genes:r:rnf121|RNF121]]|0.455|
|[[:human genes:c:cbwd6|CBWD6]]|0.454|
|[[:human genes:d:disp2|DISP2]]|0.452|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.452|
|[[:human genes:v:vasn|VASN]]|0.452|
|[[:human genes:s:sec13|SEC13]]|0.45|
|[[:human genes:k:kif3c|KIF3C]]|0.449|
|[[:human genes:c:cdc6|CDC6]]|0.447|
|[[:human genes:c:chd4|CHD4]]|0.444|
|[[:human genes:r:rrn3|RRN3]]|0.443|
|[[:human genes:p:psmc2|PSMC2]]|0.443|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.441|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.441|
|[[:human genes:p:polr2j3|POLR2J3]]|0.44|
|[[:human genes:c:cdc73|CDC73]]|0.44|
|[[:human genes:c:cdc45|CDC45]]|0.439|
|[[:human genes:z:znf106|ZNF106]]|0.437|
|[[:human genes:o:orc1|ORC1]]|0.436|
|[[:human genes:s:sult2b1|SULT2B1]]|0.435|
|[[:human genes:z:zfand5|ZFAND5]]|0.434|
|[[:human genes:g:gosr2|GOSR2]]|0.433|
|[[:human genes:e:exosc5|EXOSC5]]|0.433|
|[[:human genes:m:myh2|MYH2]]|0.432|
|[[:human genes:s:slc4a1|SLC4A1]]|0.43|
|[[:human genes:s:syt9|SYT9]]|0.43|
|[[:human genes:z:znf655|ZNF655]]|0.428|
|[[:human genes:p:psmd11|PSMD11]]|0.426|
|[[:human genes:p:psmb4|PSMB4]]|0.425|
|[[:human genes:c:cope|COPE]]|0.425|
|[[:human genes:m:myb|MYB]]|0.424|
|[[:human genes:m:myo1h|MYO1H]]|0.424|
|[[:human genes:s:stil|STIL]]|0.424|
|[[:human genes:p:paf1|PAF1]]|0.423|
|[[:human genes:r:rbbp5|RBBP5]]|0.422|
|[[:human genes:a:acsf2|ACSF2]]|0.421|
|[[:human genes:i:igfn1|IGFN1]]|0.42|
|[[:human genes:s:smg7|SMG7]]|0.419|
|[[:human genes:t:tpx2|TPX2]]|0.419|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.419|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.419|
|[[:human genes:o:ogfr|OGFR]]|0.419|
|[[:human genes:r:rad21|RAD21]]|0.419|
|[[:human genes:m:myt1l|MYT1L]]|0.418|
|[[:human genes:r:rps2|RPS2]]|0.418|
|[[:human genes:p:psmd7|PSMD7]]|0.418|
|[[:human genes:p:psma6|PSMA6]]|0.418|
|[[:human genes:a:ankle2|ANKLE2]]|0.417|
|[[:human genes:s:supt5h|SUPT5H]]|0.417|
|[[:human genes:p:psmc6|PSMC6]]|0.417|
|[[:human genes:p:polr2d|POLR2D]]|0.417|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.416|
|[[:human genes:n:nup205|NUP205]]|0.413|
|[[:human genes:d:dock6|DOCK6]]|0.412|
|[[:human genes:r:rps28|RPS28]]|0.411|
|[[:human genes:r:rad51|RAD51]]|0.41|
|[[:human genes:c:cox8a|COX8A]]|0.409|
|[[:human genes:r:rbm39|RBM39]]|0.408|
|[[:human genes:m:med17|MED17]]|0.407|
|[[:human genes:f:fam160a1|FAM160A1]]|0.406|
|[[:human genes:t:tspy8|TSPY8]]|0.405|
|[[:human genes:e:eif4a3|EIF4A3]]|0.405|
|[[:human genes:m:mylk3|MYLK3]]|0.404|
|[[:human genes:p:psmd2|PSMD2]]|0.404|
|[[:human genes:t:tceb3c|TCEB3C]]|0.403|
|[[:human genes:c:cdca3|CDCA3]]|0.403|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.401|
|[[:human genes:d:ddx51|DDX51]]|0.401|
|[[:human genes:c:copb1|COPB1]]|0.4|
|[[:human genes:n:nbpf10|NBPF10]]|0.4|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|2/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2426
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HIST2H2BF Expression in NALM6 Cells: 0.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>