======= HLA-B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HLA-B
  * **<color #00a2e8>Official Name</color>**: major histocompatibility complex, class I, B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3106|3106]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01889|P01889]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HLA-B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HLA-B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142830|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MHC I C|
|C1-set|
|MHC I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway|
|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|
|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|
|antigen processing and presentation of peptide antigen via MHC class Ib|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|
|MHC class I protein complex|
|antigen processing and presentation of endogenous peptide antigen via MHC class I|
|antigen processing and presentation of endogenous peptide antigen|
|antigen processing and presentation via MHC class Ib|
|antigen processing and presentation of endogenous antigen|
|positive regulation of T cell mediated cytotoxicity|
|integral component of lumenal side of endoplasmic reticulum membrane|
|peptide antigen binding|
|regulation of T cell mediated cytotoxicity|
|positive regulation of T cell mediated immunity|
|ER to Golgi transport vesicle membrane|
|positive regulation of leukocyte mediated cytotoxicity|
|type I interferon signaling pathway|
|cellular response to type I interferon|
|positive regulation of cell killing|
|regulation of T cell mediated immunity|
|response to type I interferon|
|interferon-gamma-mediated signaling pathway|
|phagocytic vesicle membrane|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|regulation of leukocyte mediated cytotoxicity|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|recycling endosome membrane|
|antigen processing and presentation of peptide antigen via MHC class I|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|positive regulation of leukocyte mediated immunity|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|early endosome membrane|
|regulation of adaptive immune response|
|cellular response to interferon-gamma|
|antigen processing and presentation of exogenous peptide antigen|
|response to interferon-gamma|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|regulation of leukocyte mediated immunity|
|antigen processing and presentation|
|positive regulation of immune effector process|
|signaling receptor binding|
|external side of plasma membrane|
|regulation of immune effector process|
|cell surface|
|Golgi membrane|
|cytokine-mediated signaling pathway|
|innate immune response|
|positive regulation of immune response|
|defense response to other organism|
|Golgi apparatus|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|response to cytokine|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|extracellular space|
|regulation of immune system process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.89|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14936
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HLA-B Expression in NALM6 Cells: 9.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>