======= HLA-F =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HLA-F
  * **<color #00a2e8>Official Name</color>**: major histocompatibility complex, class I, F
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3134|3134]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30511|P30511]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HLA-F&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HLA-F|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/143110|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1-set|
|MHC I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of natural killer cell degranulation|
|MHC class Ib protein complex|
|negative regulation of natural killer cell cytokine production|
|antigen processing and presentation of exogenous peptide antigen via MHC class Ib|
|regulation of natural killer cell degranulation|
|positive regulation of natural killer cell degranulation|
|TAP1 binding|
|TAP2 binding|
|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway|
|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|
|positive regulation of natural killer cell cytokine production|
|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|
|regulation of natural killer cell cytokine production|
|beta-2-microglobulin binding|
|negative regulation of natural killer cell activation|
|antigen processing and presentation of peptide antigen via MHC class Ib|
|negative regulation of T cell cytokine production|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|
|MHC class I protein complex|
|negative regulation of leukocyte degranulation|
|antigen processing and presentation of endogenous peptide antigen via MHC class I|
|negative regulation of natural killer cell mediated cytotoxicity|
|antigen processing and presentation of endogenous peptide antigen|
|negative regulation of natural killer cell mediated immunity|
|antigen processing and presentation via MHC class Ib|
|negative regulation of leukocyte mediated cytotoxicity|
|negative regulation of T cell mediated immunity|
|positive regulation of natural killer cell activation|
|antigen processing and presentation of endogenous antigen|
|negative regulation of cell killing|
|positive regulation of leukocyte degranulation|
|negative regulation of cytokine production involved in immune response|
|negative regulation of regulated secretory pathway|
|positive regulation of T cell mediated cytotoxicity|
|14-3-3 protein binding|
|integral component of lumenal side of endoplasmic reticulum membrane|
|positive regulation of natural killer cell mediated cytotoxicity|
|regulation of T cell cytokine production|
|positive regulation of natural killer cell mediated immunity|
|regulation of natural killer cell activation|
|peptide antigen binding|
|regulation of T cell mediated cytotoxicity|
|negative regulation of exocytosis|
|negative regulation of production of molecular mediator of immune response|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|negative regulation of adaptive immune response|
|positive regulation of T cell mediated immunity|
|negative regulation of leukocyte mediated immunity|
|regulation of leukocyte degranulation|
|positive regulation of regulated secretory pathway|
|ER to Golgi transport vesicle membrane|
|positive regulation of cytokine production involved in immune response|
|positive regulation of leukocyte mediated cytotoxicity|
|negative regulation of innate immune response|
|type I interferon signaling pathway|
|cellular response to type I interferon|
|positive regulation of cell killing|
|regulation of T cell mediated immunity|
|response to type I interferon|
|interferon-gamma-mediated signaling pathway|
|phagocytic vesicle membrane|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|regulation of leukocyte mediated cytotoxicity|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|recycling endosome membrane|
|regulation of cytokine production involved in immune response|
|positive regulation of exocytosis|
|negative regulation of response to biotic stimulus|
|positive regulation of production of molecular mediator of immune response|
|antigen processing and presentation of peptide antigen via MHC class I|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|negative regulation of immune effector process|
|positive regulation of leukocyte mediated immunity|
|regulation of production of molecular mediator of immune response|
|negative regulation of lymphocyte activation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|early endosome membrane|
|regulation of adaptive immune response|
|cellular response to interferon-gamma|
|regulation of regulated secretory pathway|
|negative regulation of leukocyte activation|
|antigen processing and presentation of exogenous peptide antigen|
|response to interferon-gamma|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|negative regulation of cell activation|
|negative regulation of secretion by cell|
|regulation of leukocyte mediated immunity|
|negative regulation of neuron death|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|antigen processing and presentation|
|positive regulation of immune effector process|
|regulation of exocytosis|
|negative regulation of secretion|
|negative regulation of cytokine production|
|lysosomal membrane|
|regulation of neuron death|
|signaling receptor binding|
|positive regulation of innate immune response|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|external side of plasma membrane|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of cell activation|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|negative regulation of transport|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|regulation of vesicle-mediated transport|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|cell surface|
|Golgi membrane|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of secretion|
|positive regulation of immune response|
|defense response to other organism|
|positive regulation of transport|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5746
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HLA-F Expression in NALM6 Cells: 4.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>