======= HLA-G =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HLA-G
  * **<color #00a2e8>Official Name</color>**: major histocompatibility complex, class I, G
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3135|3135]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17693|P17693]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HLA-G&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HLA-G|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142871|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MHC I|
|C1-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|B cell tolerance induction|
|peripheral B cell tolerance induction|
|tolerance induction dependent upon immune response|
|peripheral tolerance induction|
|CD8 receptor binding|
|protection from natural killer cell mediated cytotoxicity|
|cis-Golgi network membrane|
|negative regulation of dendritic cell differentiation|
|immune response-inhibiting cell surface receptor signaling pathway|
|positive regulation of T cell tolerance induction|
|positive regulation of natural killer cell cytokine production|
|negative regulation of T cell mediated cytotoxicity|
|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway|
|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|
|immune response-inhibiting signal transduction|
|regulation of natural killer cell cytokine production|
|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|
|positive regulation of tolerance induction|
|regulation of T cell tolerance induction|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|
|positive regulation of macrophage cytokine production|
|antigen processing and presentation of peptide antigen via MHC class Ib|
|MHC class I protein complex|
|positive regulation of cellular senescence|
|regulation of dendritic cell differentiation|
|tolerance induction|
|antigen processing and presentation of endogenous peptide antigen|
|positive regulation of regulatory T cell differentiation|
|antigen processing and presentation of endogenous peptide antigen via MHC class I|
|negative regulation of natural killer cell mediated cytotoxicity|
|regulation of macrophage cytokine production|
|positive regulation of cell aging|
|negative regulation of natural killer cell mediated immunity|
|antigen processing and presentation via MHC class Ib|
|regulation of tolerance induction|
|negative regulation of leukocyte mediated cytotoxicity|
|filopodium membrane|
|positive regulation of myeloid leukocyte cytokine production involved in immune response|
|positive regulation of endothelial cell apoptotic process|
|negative regulation of T cell mediated immunity|
|antigen processing and presentation of endogenous antigen|
|negative regulation of cell killing|
|positive regulation of T cell mediated cytotoxicity|
|integral component of lumenal side of endoplasmic reticulum membrane|
|regulation of regulatory T cell differentiation|
|positive regulation of epithelial cell apoptotic process|
|protein homotrimerization|
|positive regulation of natural killer cell mediated immunity|
|regulation of T cell mediated cytotoxicity|
|peptide antigen binding|
|positive regulation of interleukin-12 production|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of G0 to G1 transition|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cellular senescence|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of G0 to G1 transition|
|regulation of natural killer cell mediated immunity|
|negative regulation of adaptive immune response|
|negative regulation of protein kinase B signaling|
|positive regulation of T cell mediated immunity|
|regulation of cell aging|
|negative regulation of leukocyte mediated immunity|
|regulation of endothelial cell apoptotic process|
|cellular defense response|
|ER to Golgi transport vesicle membrane|
|positive regulation of cytokine production involved in immune response|
|regulation of interleukin-12 production|
|protein trimerization|
|positive regulation of leukocyte mediated cytotoxicity|
|negative regulation of innate immune response|
|negative regulation of T cell proliferation|
|type I interferon signaling pathway|
|cellular response to type I interferon|
|positive regulation of cell killing|
|regulation of T cell mediated immunity|
|response to type I interferon|
|interferon-gamma-mediated signaling pathway|
|phagocytic vesicle membrane|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|regulation of leukocyte mediated cytotoxicity|
|regulation of epithelial cell apoptotic process|
|negative regulation of leukocyte proliferation|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|positive regulation of T cell differentiation|
|recycling endosome membrane|
|regulation of cytokine production involved in immune response|
|negative regulation of response to biotic stimulus|
|positive regulation of lymphocyte differentiation|
|positive regulation of production of molecular mediator of immune response|
|antigen processing and presentation of peptide antigen via MHC class I|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of leukocyte differentiation|
|regulation of cell killing|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|negative regulation of T cell activation|
|negative regulation of vasculature development|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of leukocyte mediated immunity|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|regulation of production of molecular mediator of immune response|
|negative regulation of lymphocyte activation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|early endosome membrane|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|cellular response to interferon-gamma|
|regulation of lymphocyte differentiation|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|antigen processing and presentation of exogenous peptide antigen|
|response to interferon-gamma|
|antigen processing and presentation of exogenous antigen|
|positive regulation of hemopoiesis|
|antigen processing and presentation of peptide antigen|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|regulation of lymphocyte proliferation|
|B cell mediated immunity|
|regulation of mononuclear cell proliferation|
|negative regulation of multi-organism process|
|positive regulation of leukocyte cell-cell adhesion|
|antigen processing and presentation|
|positive regulation of immune effector process|
|regulation of protein kinase B signaling|
|regulation of leukocyte proliferation|
|positive regulation of cell-cell adhesion|
|early endosome|
|lymphocyte mediated immunity|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of angiogenesis|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of vasculature development|
|negative regulation of cell cycle process|
|signaling receptor binding|
|protein homooligomerization|
|positive regulation of innate immune response|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|protein complex oligomerization|
|regulation of response to biotic stimulus|
|negative regulation of cell cycle|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|adaptive immune response|
|Golgi membrane|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|regulation of multi-organism process|
|positive regulation of immune response|
|protein homodimerization activity|
|negative regulation of developmental process|
|defense response to other organism|
|positive regulation of cell differentiation|
|cellular response to cytokine stimulus|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of response to stress|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp274|Citral 50μM R06 exp274]]|1.76|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.82|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12484
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HLA-G Expression in NALM6 Cells: 1.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>