======= HNF1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HNF1B
  * **<color #00a2e8>Official Name</color>**: HNF1 homeobox B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6928|6928]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35680|P35680]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HNF1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HNF1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189907|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HNF-1B C|
|Homeobox|
|HNF-1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis|
|hepatoblast differentiation|
|negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis|
|mesonephric duct formation|
|pronephric nephron tubule development|
|regulation of pronephros size|
|negative regulation of mesenchymal cell apoptotic process involved in metanephros development|
|pronephric nephron development|
|pronephros morphogenesis|
|regulation of mesenchymal cell apoptotic process involved in metanephros development|
|mesonephric duct morphogenesis|
|regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis|
|negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis|
|negative regulation of somatic stem cell population maintenance|
|negative regulation of mesonephros development|
|regulation of branch elongation involved in ureteric bud branching|
|regulation of kidney size|
|nephric duct formation|
|endodermal cell fate specification|
|ureteric bud elongation|
|regulation of somatic stem cell population maintenance|
|negative regulation of apoptotic process involved in morphogenesis|
|negative regulation of apoptotic process involved in development|
|mesonephric tubule formation|
|inner cell mass cell differentiation|
|negative regulation of stem cell population maintenance|
|mesonephric duct development|
|pronephros development|
|negative regulation of metanephros development|
|negative regulation of mesenchymal cell apoptotic process|
|regulation of mesenchymal cell apoptotic process|
|regulation of apoptotic process involved in morphogenesis|
|regulation of apoptotic process involved in development|
|nephric duct morphogenesis|
|hepatocyte differentiation|
|endodermal cell fate commitment|
|negative regulation of kidney development|
|nephric duct development|
|nephron tubule formation|
|embryonic digestive tract morphogenesis|
|positive regulation of transcription initiation from RNA polymerase II promoter|
|regulation of branching involved in ureteric bud morphogenesis|
|regulation of metanephros development|
|regulation of mesonephros development|
|positive regulation of DNA-templated transcription, initiation|
|regulation of transcription initiation from RNA polymerase II promoter|
|cell fate commitment involved in formation of primary germ layer|
|regulation of stem cell population maintenance|
|proximal promoter sequence-specific DNA binding|
|embryonic digestive tract development|
|negative regulation of animal organ morphogenesis|
|regulation of DNA-templated transcription, initiation|
|blastocyst formation|
|insulin secretion|
|endodermal cell differentiation|
|endoderm formation|
|digestive tract morphogenesis|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of kidney development|
|regulation of morphogenesis of a branching structure|
|peptide hormone secretion|
|circadian regulation of gene expression|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|hormone secretion|
|pancreas development|
|endoderm development|
|nephron tubule development|
|renal tubule development|
|hormone transport|
|kidney morphogenesis|
|ureteric bud development|
|epithelial cell proliferation|
|mesonephric epithelium development|
|mesonephric tubule development|
|cell fate specification|
|mesonephros development|
|nephron epithelium development|
|blastocyst development|
|formation of primary germ layer|
|developmental growth involved in morphogenesis|
|embryonic epithelial tube formation|
|nephron development|
|Notch signaling pathway|
|liver development|
|hepaticobiliary system development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|digestive tract development|
|epithelial tube formation|
|response to glucose|
|circadian rhythm|
|response to hexose|
|digestive system development|
|morphogenesis of embryonic epithelium|
|tube formation|
|response to monosaccharide|
|hindbrain development|
|protein secretion|
|stem cell differentiation|
|morphogenesis of a branching epithelium|
|establishment of protein localization to extracellular region|
|gastrulation|
|protein localization to extracellular region|
|morphogenesis of a branching structure|
|signal release|
|response to carbohydrate|
|peptide secretion|
|regulation of morphogenesis of an epithelium|
|protein-DNA complex assembly|
|transcription factor complex|
|anterior/posterior pattern specification|
|protein-DNA complex subunit organization|
|cell fate commitment|
|regulation of animal organ morphogenesis|
|protein-containing complex binding|
|kidney development|
|rhythmic process|
|renal system development|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|urogenital system development|
|regulation of developmental growth|
|regionalization|
|regulation of Wnt signaling pathway|
|in utero embryonic development|
|developmental growth|
|growth|
|gland development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|protein heterodimerization activity|
|regulation of anatomical structure size|
|regulation of hormone levels|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of growth|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|brain development|
|head development|
|cellular protein-containing complex assembly|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to organic cyclic compound|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|secretion by cell|
|response to drug|
|export from cell|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|cell-cell signaling|
|secretion|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|peptide transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|amide transport|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.76|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.81|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.83|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 52/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|12/21|
|liver|4/20|
|lung|6/75|
|lymphocyte|0/16|
|ovary|3/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7956
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HNF1B Expression in NALM6 Cells: -0.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>