======= HNRNPC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HNRNPC
  * **<color #00a2e8>Official Name</color>**: heterogeneous nuclear ribonucleoprotein C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3183|3183]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07910|P07910]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HNRNPC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HNRNPC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N6-methyladenosine-containing RNA binding|
|3-UTR-mediated mRNA stabilization|
|telomerase holoenzyme complex|
|negative regulation of telomere maintenance via telomerase|
|telomerase RNA binding|
|negative regulation of telomere maintenance via telomere lengthening|
|poly(U) RNA binding|
|negative regulation of telomere maintenance|
|negative regulation of DNA biosynthetic process|
|mRNA stabilization|
|nucleosomal DNA binding|
|RNA stabilization|
|negative regulation of mRNA catabolic process|
|regulation of telomere maintenance via telomerase|
|negative regulation of RNA catabolic process|
|regulation of telomere maintenance via telomere lengthening|
|ATP-dependent chromatin remodeling|
|mRNA 3-UTR binding|
|negative regulation of mRNA metabolic process|
|regulation of telomere maintenance|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|regulation of DNA biosynthetic process|
|negative regulation of DNA metabolic process|
|osteoblast differentiation|
|negative regulation of chromosome organization|
|chromatin remodeling|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|actin cytoskeleton|
|nuclear chromatin|
|negative regulation of cellular catabolic process|
|ossification|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|negative regulation of catabolic process|
|regulation of mRNA metabolic process|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|RNA splicing|
|mRNA processing|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|posttranscriptional regulation of gene expression|
|protein-containing complex|
|mRNA metabolic process|
|chromatin organization|
|negative regulation of cellular component organization|
|regulation of cellular catabolic process|
|RNA processing|
|regulation of catabolic process|
|chromosome organization|
|identical protein binding|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|RNA metabolic process|
|extracellular region|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.71|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.74|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.76|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chd4|CHD4]]|0.49|
|[[:human genes:t:ticrr|TICRR]]|0.485|
|[[:human genes:a:ankle2|ANKLE2]]|0.483|
|[[:human genes:c:copg1|COPG1]]|0.461|
|[[:human genes:f:fbxw9|FBXW9]]|0.456|
|[[:human genes:v:vasn|VASN]]|0.455|
|[[:human genes:c:cbwd3|CBWD3]]|0.45|
|[[:human genes:r:rrp15|RRP15]]|0.449|
|[[:human genes:c:cbwd6|CBWD6]]|0.448|
|[[:human genes:k:kctd17|KCTD17]]|0.446|
|[[:human genes:r:rps12|RPS12]]|0.444|
|[[:human genes:c:cbwd5|CBWD5]]|0.438|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.435|
|[[:human genes:t:tceb3c|TCEB3C]]|0.433|
|[[:human genes:t:tfip11|TFIP11]]|0.433|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.432|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.432|
|[[:human genes:s:sf3a3|SF3A3]]|0.432|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.428|
|[[:human genes:c:copa|COPA]]|0.419|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.419|
|[[:human genes:m:med14|MED14]]|0.415|
|[[:human genes:n:nup160|NUP160]]|0.415|
|[[:human genes:c:cactin|CACTIN]]|0.41|
|[[:human genes:h:heatr1|HEATR1]]|0.409|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.409|
|[[:human genes:c:ckap5|CKAP5]]|0.408|
|[[:human genes:e:exosc3|EXOSC3]]|0.408|
|[[:human genes:d:ddtl|DDTL]]|0.408|
|[[:human genes:t:twistnb|TWISTNB]]|0.408|
|[[:human genes:p:psmd3|PSMD3]]|0.407|
|[[:human genes:s:sap30bp|SAP30BP]]|0.407|
|[[:human genes:r:rps2|RPS2]]|0.407|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.405|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.403|
|[[:human genes:g:gid4|GID4]]|0.403|
|[[:human genes:n:nupl1|NUPL1]]|0.402|
|[[:human genes:n:npipb5|NPIPB5]]|0.401|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.4|
|[[:human genes:s:slc4a1|SLC4A1]]|0.4|
|[[:human genes:r:rbm39|RBM39]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 308/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|11/28|
|blood|8/28|
|bone|15/25|
|breast|12/33|
|central nervous system|30/56|
|cervix|2/4|
|colorectal|7/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|6/15|
|kidney|14/21|
|liver|11/20|
|lung|28/75|
|lymphocyte|7/14|
|ovary|14/26|
|pancreas|5/24|
|peripheral nervous system|6/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|13/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|10/22|
|urinary tract|12/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1493
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HNRNPC Expression in NALM6 Cells: 9.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>