======= HPGD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HPGD
  * **<color #00a2e8>Official Name</color>**: 15-hydroxyprostaglandin dehydrogenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3248|3248]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15428|P15428]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HPGD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HPGD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601688|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|adh short|
|Epimerase|
|KR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|15-hydroxyprostaglandin dehydrogenase (NAD+) activity|
|prostaglandin E receptor activity|
|ductus arteriosus closure|
|lipoxin metabolic process|
|lipoxin biosynthetic process|
|thrombin-activated receptor signaling pathway|
|parturition|
|lipoxygenase pathway|
|NAD+ binding|
|ovulation|
|long-chain fatty acid biosynthetic process|
|positive regulation of vascular smooth muscle cell proliferation|
|prostaglandin metabolic process|
|prostanoid metabolic process|
|NAD binding|
|unsaturated fatty acid biosynthetic process|
|catalytic activity|
|icosanoid biosynthetic process|
|regulation of vascular smooth muscle cell proliferation|
|artery morphogenesis|
|artery development|
|positive regulation of smooth muscle cell proliferation|
|fatty acid derivative biosynthetic process|
|transforming growth factor beta receptor signaling pathway|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|response to ethanol|
|female gamete generation|
|regulation of smooth muscle cell proliferation|
|response to estradiol|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|fatty acid derivative metabolic process|
|female pregnancy|
|monocarboxylic acid biosynthetic process|
|basolateral plasma membrane|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|multi-multicellular organism process|
|response to alcohol|
|kidney development|
|renal system development|
|carboxylic acid biosynthetic process|
|response to antibiotic|
|organic acid biosynthetic process|
|response to lipopolysaccharide|
|urogenital system development|
|fatty acid metabolic process|
|response to molecule of bacterial origin|
|blood vessel morphogenesis|
|blood vessel development|
|cellular response to growth factor stimulus|
|response to toxic substance|
|vasculature development|
|cardiovascular system development|
|monocarboxylic acid metabolic process|
|response to growth factor|
|negative regulation of cell cycle|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|response to bacterium|
|gamete generation|
|positive regulation of cell death|
|enzyme linked receptor protein signaling pathway|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|circulatory system development|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|oxidation-reduction process|
|multi-organism reproductive process|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|regulation of cell cycle|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of cell death|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.542|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16021
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HPGD Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>