======= HPGDS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HPGDS
  * **<color #00a2e8>Official Name</color>**: hematopoietic prostaglandin D synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27306|27306]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60760|O60760]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HPGDS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HPGDS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602598|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. {ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:19939518, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GST C|
|GST N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prostaglandin-D synthase activity|
|negative regulation of male germ cell proliferation|
|negative regulation of germ cell proliferation|
|regulation of germ cell proliferation|
|regulation of male germ cell proliferation|
|cyclooxygenase pathway|
|prostaglandin biosynthetic process|
|prostanoid biosynthetic process|
|glutathione derivative metabolic process|
|glutathione derivative biosynthetic process|
|glutathione transferase activity|
|prostaglandin metabolic process|
|prostanoid metabolic process|
|unsaturated fatty acid biosynthetic process|
|icosanoid biosynthetic process|
|glutathione metabolic process|
|negative regulation of reproductive process|
|arachidonic acid metabolic process|
|fatty acid derivative biosynthetic process|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|regulation of reproductive process|
|fatty acid derivative metabolic process|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|locomotory behavior|
|cellular modified amino acid metabolic process|
|negative regulation of multi-organism process|
|magnesium ion binding|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|sulfur compound metabolic process|
|cofactor metabolic process|
|peptide metabolic process|
|monocarboxylic acid metabolic process|
|behavior|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|negative regulation of cell population proliferation|
|calcium ion binding|
|regulation of multi-organism process|
|cellular amide metabolic process|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|regulation of cell population proliferation|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18481
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HPGDS Expression in NALM6 Cells: -1.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>