======= HSPD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSPD1
  * **<color #00a2e8>Official Name</color>**: heat shock protein family D (Hsp60) member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3329|3329]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10809|P10809]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSPD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSPD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118190|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cpn60 TCP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|isotype switching to IgG isotypes|
|B cell cytokine production|
|protein import into mitochondrial intermembrane space|
|positive regulation of T cell mediated immune response to tumor cell|
|regulation of T cell mediated immune response to tumor cell|
|coated vesicle|
|apolipoprotein A-I binding|
|lipopolysaccharide receptor complex|
|high-density lipoprotein particle binding|
|positive regulation of immune response to tumor cell|
|positive regulation of response to tumor cell|
|adhesion of symbiont to host|
|regulation of response to tumor cell|
|regulation of immune response to tumor cell|
|isomerase activity|
|apolipoprotein binding|
|chaperone-mediated protein complex assembly|
|somatic diversification of immunoglobulins involved in immune response|
|somatic recombination of immunoglobulin genes involved in immune response|
|isotype switching|
|cytokine production involved in immune response|
|positive regulation of interferon-alpha production|
|somatic recombination of immunoglobulin gene segments|
|positive regulation of macrophage activation|
|DNA replication origin binding|
|immunoglobulin production involved in immunoglobulin mediated immune response|
|regulation of interferon-alpha production|
|MyD88-dependent toll-like receptor signaling pathway|
|protein transmembrane import into intracellular organelle|
|lipopolysaccharide binding|
|positive regulation of interleukin-12 production|
|somatic cell DNA recombination|
|somatic diversification of immune receptors via germline recombination within a single locus|
|somatic diversification of immunoglobulins|
|positive regulation of interleukin-10 production|
|protein refolding|
|de novo protein folding|
|B cell proliferation|
|B cell activation involved in immune response|
|positive regulation of T cell mediated immunity|
|intracellular protein transmembrane transport|
|somatic diversification of immune receptors|
|response to cold|
|regulation of interleukin-10 production|
|regulation of macrophage activation|
|regulation of interleukin-12 production|
|clathrin-coated pit|
|protein targeting to mitochondrion|
|apoptotic mitochondrial changes|
|protein transmembrane transport|
|positive regulation of interferon-gamma production|
|p53 binding|
|regulation of T cell mediated immunity|
|establishment of protein localization to mitochondrion|
|double-stranded RNA binding|
|interaction with symbiont|
|protein localization to mitochondrion|
|positive regulation of type I interferon production|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|secretory granule|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|mitochondrial transmembrane transport|
|positive regulation of interleukin-6 production|
|leukocyte proliferation|
|regulation of interferon-gamma production|
|toll-like receptor signaling pathway|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|chaperone binding|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|single-stranded DNA binding|
|lymphocyte activation involved in immune response|
|regulation of type I interferon production|
|pattern recognition receptor signaling pathway|
|unfolded protein binding|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of leukocyte mediated immunity|
|regulation of interleukin-6 production|
|protein import|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|cytokine production|
|regulation of lymphocyte mediated immunity|
|positive regulation of cysteine-type endopeptidase activity|
|B cell activation|
|immunoglobulin production|
|regulation of adaptive immune response|
|response to unfolded protein|
|positive regulation of endopeptidase activity|
|response to temperature stimulus|
|protein stabilization|
|production of molecular mediator of immune response|
|response to topologically incorrect protein|
|positive regulation of peptidase activity|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|mitochondrial transport|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|DNA recombination|
|protein maturation|
|protein folding|
|innate immune response-activating signal transduction|
|T cell activation|
|ATPase activity|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of cell-cell adhesion|
|early endosome|
|activation of innate immune response|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|positive regulation of innate immune response|
|enzyme binding|
|protein targeting|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|mitochondrial matrix|
|lymphocyte activation|
|mitochondrial inner membrane|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|establishment of protein localization to organelle|
|mitochondrion organization|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|cell population proliferation|
|immune response-activating signal transduction|
|protein-containing complex|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|adaptive immune response|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of cell death|
|viral process|
|regulation of proteolysis|
|protein localization to organelle|
|DNA metabolic process|
|regulation of defense response|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|leukocyte activation|
|biological adhesion|
|intracellular protein transport|
|negative regulation of cell death|
|programmed cell death|
|cell activation|
|cell death|
|immune effector process|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|mitochondrion|
|regulation of hydrolase activity|
|transmembrane transport|
|RNA binding|
|positive regulation of catalytic activity|
|regulation of response to stress|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|immune response|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.72|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.72|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.73|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.75|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.8|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.83|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.88|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.96|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.09|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.24|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.48|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.62|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.66|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.74|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.78|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.1|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|3.33|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rnmt|RNMT]]|0.664|
|[[:human genes:h:hars|HARS]]|0.659|
|[[:human genes:g:gmppb|GMPPB]]|0.658|
|[[:human genes:g:gfpt1|GFPT1]]|0.643|
|[[:human genes:c:casp9|CASP9]]|0.627|
|[[:human genes:t:triap1|TRIAP1]]|0.62|
|[[:human genes:a:apaf1|APAF1]]|0.619|
|[[:human genes:e:eny2|ENY2]]|0.618|
|[[:human genes:p:plaa|PLAA]]|0.617|
|[[:human genes:h:hccs|HCCS]]|0.608|
|[[:human genes:u:uap1|UAP1]]|0.607|
|[[:human genes:c:csnk2b|CSNK2B]]|0.595|
|[[:human genes:t:thg1l|THG1L]]|0.594|
|[[:human genes:r:rptor|RPTOR]]|0.594|
|[[:human genes:m:meaf6|MEAF6]]|0.593|
|[[:human genes:d:dpagt1|DPAGT1]]|0.588|
|[[:human genes:a:atp5j|ATP5J]]|0.573|
|[[:human genes:p:pmm2|PMM2]]|0.571|
|[[:human genes:m:mars|MARS]]|0.571|
|[[:human genes:e:eif4e|EIF4E]]|0.57|
|[[:human genes:r:rtcb|RTCB]]|0.569|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.568|
|[[:human genes:c:cct7|CCT7]]|0.563|
|[[:human genes:c:cycs|CYCS]]|0.561|
|[[:human genes:s:slc35b1|SLC35B1]]|0.559|
|[[:human genes:a:alg1|ALG1]]|0.558|
|[[:human genes:f:faf2|FAF2]]|0.558|
|[[:human genes:a:atp5o|ATP5O]]|0.557|
|[[:human genes:m:mtor|MTOR]]|0.557|
|[[:human genes:n:nae1|NAE1]]|0.555|
|[[:human genes:p:pam16|PAM16]]|0.553|
|[[:human genes:d:diablo|DIABLO]]|0.551|
|[[:human genes:b:bak1|BAK1]]|0.55|
|[[:human genes:a:atp5b|ATP5B]]|0.548|
|[[:human genes:a:alg2|ALG2]]|0.545|
|[[:human genes:n:nars|NARS]]|0.544|
|[[:human genes:u:ubqln1|UBQLN1]]|0.542|
|[[:human genes:d:dhdds|DHDDS]]|0.542|
|[[:human genes:s:sec61g|SEC61G]]|0.539|
|[[:human genes:d:dohh|DOHH]]|0.537|
|[[:human genes:s:spcs2|SPCS2]]|0.536|
|[[:human genes:a:aars|AARS]]|0.534|
|[[:human genes:s:seh1l|SEH1L]]|0.527|
|[[:human genes:a:adsl|ADSL]]|0.526|
|[[:human genes:c:cep350|CEP350]]|0.526|
|[[:human genes:e:exoc4|EXOC4]]|0.525|
|[[:human genes:c:cars|CARS]]|0.523|
|[[:human genes:m:march5|MARCH5]]|0.522|
|[[:human genes:d:dhps|DHPS]]|0.519|
|[[:human genes:a:alg5|ALG5]]|0.519|
|[[:human genes:s:spcs3|SPCS3]]|0.517|
|[[:human genes:u:ube2g2|UBE2G2]]|0.517|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.517|
|[[:human genes:d:dad1|DAD1]]|0.516|
|[[:human genes:s:srp14|SRP14]]|0.513|
|[[:human genes:a:atp5a1|ATP5A1]]|0.513|
|[[:human genes:c:ccdc101|CCDC101]]|0.513|
|[[:human genes:t:taz|TAZ]]|0.511|
|[[:human genes:g:gabpa|GABPA]]|0.51|
|[[:human genes:r:rpn1|RPN1]]|0.509|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.505|
|[[:human genes:t:tmem41b|TMEM41B]]|0.504|
|[[:human genes:g:gnb1l|GNB1L]]|0.498|
|[[:human genes:p:pelo|PELO]]|0.498|
|[[:human genes:b:bap1|BAP1]]|0.498|
|[[:human genes:y:yars|YARS]]|0.498|
|[[:human genes:g:gtf3a|GTF3A]]|0.497|
|[[:human genes:o:oraov1|ORAOV1]]|0.496|
|[[:human genes:u:ube2k|UBE2K]]|0.495|
|[[:human genes:u:utp23|UTP23]]|0.495|
|[[:human genes:p:pisd|PISD]]|0.495|
|[[:human genes:t:tsen34|TSEN34]]|0.494|
|[[:human genes:t:tamm41|TAMM41]]|0.49|
|[[:human genes:u:uba3|UBA3]]|0.489|
|[[:human genes:v:vrk1|VRK1]]|0.485|
|[[:human genes:a:alg13|ALG13]]|0.483|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.482|
|[[:human genes:p:ppa2|PPA2]]|0.481|
|[[:human genes:v:vdac2|VDAC2]]|0.48|
|[[:human genes:w:wdr24|WDR24]]|0.479|
|[[:human genes:t:tbca|TBCA]]|0.477|
|[[:human genes:v:vezt|VEZT]]|0.476|
|[[:human genes:a:abcb7|ABCB7]]|0.474|
|[[:human genes:n:nxt1|NXT1]]|0.474|
|[[:human genes:c:crls1|CRLS1]]|0.473|
|[[:human genes:r:rpp21|RPP21]]|0.472|
|[[:human genes:t:tsen54|TSEN54]]|0.47|
|[[:human genes:e:eif3f|EIF3F]]|0.468|
|[[:human genes:r:romo1|ROMO1]]|0.467|
|[[:human genes:r:rad1|RAD1]]|0.467|
|[[:human genes:p:polr3h|POLR3H]]|0.466|
|[[:human genes:m:med16|MED16]]|0.465|
|[[:human genes:s:srp72|SRP72]]|0.464|
|[[:human genes:t:tti2|TTI2]]|0.464|
|[[:human genes:r:rpe|RPE]]|0.463|
|[[:human genes:e:eprs|EPRS]]|0.463|
|[[:human genes:s:sec16a|SEC16A]]|0.462|
|[[:human genes:t:trnt1|TRNT1]]|0.462|
|[[:human genes:t:tbcd|TBCD]]|0.459|
|[[:human genes:a:atp5f1|ATP5F1]]|0.457|
|[[:human genes:a:atxn10|ATXN10]]|0.456|
|[[:human genes:m:mfn1|MFN1]]|0.455|
|[[:human genes:n:nupl2|NUPL2]]|0.454|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.453|
|[[:human genes:t:timm13|TIMM13]]|0.453|
|[[:human genes:g:gfer|GFER]]|0.45|
|[[:human genes:u:uba5|UBA5]]|0.449|
|[[:human genes:n:nsmce1|NSMCE1]]|0.448|
|[[:human genes:s:sgol1|SGOL1]]|0.448|
|[[:human genes:t:tgs1|TGS1]]|0.447|
|[[:human genes:w:wars|WARS]]|0.447|
|[[:human genes:e:exoc3|EXOC3]]|0.44|
|[[:human genes:a:alg14|ALG14]]|0.44|
|[[:human genes:t:telo2|TELO2]]|0.438|
|[[:human genes:d:dkc1|DKC1]]|0.438|
|[[:human genes:p:phb2|PHB2]]|0.437|
|[[:human genes:c:cbfb|CBFB]]|0.437|
|[[:human genes:u:uhrf1|UHRF1]]|0.436|
|[[:human genes:t:tle4|TLE4]]|0.436|
|[[:human genes:a:abcf1|ABCF1]]|0.435|
|[[:human genes:d:dicer1|DICER1]]|0.434|
|[[:human genes:k:kif14|KIF14]]|0.433|
|[[:human genes:t:timm22|TIMM22]]|0.433|
|[[:human genes:t:trmt5|TRMT5]]|0.432|
|[[:human genes:t:txnl4b|TXNL4B]]|0.432|
|[[:human genes:w:wdr59|WDR59]]|0.432|
|[[:human genes:t:thoc6|THOC6]]|0.431|
|[[:human genes:d:ddx20|DDX20]]|0.431|
|[[:human genes:m:mllt1|MLLT1]]|0.431|
|[[:human genes:r:rabggtb|RABGGTB]]|0.431|
|[[:human genes:h:haus8|HAUS8]]|0.431|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.43|
|[[:human genes:o:oip5|OIP5]]|0.43|
|[[:human genes:o:osgep|OSGEP]]|0.429|
|[[:human genes:a:atp2a2|ATP2A2]]|0.428|
|[[:human genes:a:atp5i|ATP5I]]|0.427|
|[[:human genes:d:ddost|DDOST]]|0.426|
|[[:human genes:b:bub3|BUB3]]|0.426|
|[[:human genes:v:vmp1|VMP1]]|0.426|
|[[:human genes:t:thoc3|THOC3]]|0.424|
|[[:human genes:u:ube2j1|UBE2J1]]|0.423|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.422|
|[[:human genes:a:atad1|ATAD1]]|0.419|
|[[:human genes:e:eno1|ENO1]]|0.418|
|[[:human genes:a:atp5d|ATP5D]]|0.417|
|[[:human genes:o:otud5|OTUD5]]|0.416|
|[[:human genes:k:kdsr|KDSR]]|0.416|
|[[:human genes:d:dr1|DR1]]|0.415|
|[[:human genes:n:naf1|NAF1]]|0.415|
|[[:human genes:s:srp68|SRP68]]|0.414|
|[[:human genes:z:zrsr2|ZRSR2]]|0.413|
|[[:human genes:p:phb|PHB]]|0.412|
|[[:human genes:p:pmpcb|PMPCB]]|0.412|
|[[:human genes:t:txnrd1|TXNRD1]]|0.411|
|[[:human genes:d:dnajc3|DNAJC3]]|0.411|
|[[:human genes:t:thoc7|THOC7]]|0.41|
|[[:human genes:v:vhl|VHL]]|0.409|
|[[:human genes:u:ube2m|UBE2M]]|0.408|
|[[:human genes:p:polr3b|POLR3B]]|0.408|
|[[:human genes:t:tsen2|TSEN2]]|0.406|
|[[:human genes:p:pax5|PAX5]]|0.405|
|[[:human genes:t:tti1|TTI1]]|0.404|
|[[:human genes:d:dpf2|DPF2]]|0.404|
|[[:human genes:s:ssb|SSB]]|0.403|
|[[:human genes:d:dolk|DOLK]]|0.403|
|[[:human genes:p:pdpk1|PDPK1]]|0.403|
|[[:human genes:c:cdipt|CDIPT]]|0.402|
|[[:human genes:t:ttc4|TTC4]]|0.401|
|[[:human genes:a:alg6|ALG6]]|0.401|
|[[:human genes:s:sdha|SDHA]]|0.4|
|[[:human genes:e:elac2|ELAC2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 643/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|25/28|
|bone|23/26|
|breast|29/33|
|central nervous system|51/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|19/21|
|liver|17/20|
|lung|64/75|
|lymphocyte|11/16|
|ovary|24/26|
|pancreas|20/24|
|peripheral nervous system|12/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1625
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSPD1 Expression in NALM6 Cells: 10.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>