======= HSPG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSPG2
  * **<color #00a2e8>Official Name</color>**: heparan sulfate proteoglycan 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3339|3339]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P98160|P98160]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSPG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSPG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142461|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin EGF|
|Ldl recept a|
|Laminin G 2|
|Laminin G 1|
|I-set|
|EGF|
|Laminin B|
|ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plasma membrane protein complex|
|extracellular matrix structural constituent conferring compression resistance|
|low-density lipoprotein particle receptor binding|
|substrate adhesion-dependent cell spreading|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|amyloid-beta binding|
|basement membrane|
|lysosomal lumen|
|Golgi lumen|
|negative regulation of angiogenesis|
|retinoid metabolic process|
|glycosaminoglycan biosynthetic process|
|negative regulation of blood vessel morphogenesis|
|aminoglycan biosynthetic process|
|diterpenoid metabolic process|
|negative regulation of vasculature development|
|terpenoid metabolic process|
|isoprenoid metabolic process|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|cell-substrate adhesion|
|protein C-terminus binding|
|carbohydrate derivative catabolic process|
|receptor-mediated endocytosis|
|regulation of angiogenesis|
|angiogenesis|
|regulation of vasculature development|
|extracellular matrix organization|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|blood vessel morphogenesis|
|focal adhesion|
|blood vessel development|
|inflammatory response|
|vasculature development|
|cardiovascular system development|
|endocytosis|
|cell morphogenesis involved in differentiation|
|carbohydrate derivative biosynthetic process|
|tube morphogenesis|
|import into cell|
|calcium ion binding|
|cell morphogenesis|
|brain development|
|head development|
|cellular component morphogenesis|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|cell migration|
|central nervous system development|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|localization of cell|
|cell motility|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|locomotion|
|defense response|
|organonitrogen compound biosynthetic process|
|movement of cell or subcellular component|
|extracellular space|
|cell development|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.41|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.86|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3521
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSPG2 Expression in NALM6 Cells: 2.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>