======= HTR2A =======
== Gene Information ==
* **Official Symbol**: HTR2A
* **Official Name**: 5-hydroxytryptamine receptor 2A
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3356|3356]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P28223|P28223]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=HTR2A&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HTR2A|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/182135|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
* **UniProt Summary**: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. {ECO:0000269|PubMed:1330647, ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:21645528, ECO:0000269|PubMed:22300836, ECO:0000269|PubMed:28129538}.
|7tm 1|
|7TM GPCR Srsx|
|1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|
|phospholipase C-activating serotonin receptor signaling pathway|
|positive regulation of phosphatidylinositol biosynthetic process|
|urinary tract smooth muscle contraction|
|cell body fiber|
|urinary bladder smooth muscle contraction|
|regulation of phosphatidylinositol biosynthetic process|
|negative regulation of synaptic transmission, glutamatergic|
|artery smooth muscle contraction|
|serotonin binding|
|tonic smooth muscle contraction|
|positive regulation of phospholipid biosynthetic process|
|detection of mechanical stimulus involved in sensory perception of pain|
|sleep|
|detection of temperature stimulus involved in sensory perception of pain|
|detection of temperature stimulus involved in sensory perception|
|vascular smooth muscle contraction|
|regulation of phospholipid biosynthetic process|
|detection of temperature stimulus|
|behavioral response to cocaine|
|sensory perception of temperature stimulus|
|positive regulation of glycolytic process|
|G-protein alpha-subunit binding|
|detection of mechanical stimulus involved in sensory perception|
|temperature homeostasis|
|positive regulation of vasoconstriction|
|vasoconstriction|
|activation of phospholipase C activity|
|negative regulation of potassium ion transport|
|phosphatidylinositol 3-kinase signaling|
|G protein-coupled serotonin receptor signaling pathway|
|G protein-coupled serotonin receptor activity|
|dendritic shaft|
|neurotransmitter receptor activity|
|negative regulation of blood vessel diameter|
|protein localization to cytoskeleton|
|serotonin receptor signaling pathway|
|regulation of dopamine secretion|
|positive regulation of phospholipase C activity|
|detection of mechanical stimulus|
|integral component of postsynaptic membrane|
|positive regulation of ATP metabolic process|
|positive regulation of nucleotide metabolic process|
|positive regulation of purine nucleotide metabolic process|
|regulation of phospholipase C activity|
|positive regulation of phospholipid metabolic process|
|smooth muscle contraction|
|response to cocaine|
|release of sequestered calcium ion into cytosol|
|regulation of vasoconstriction|
|drug binding|
|negative regulation of sequestering of calcium ion|
|integral component of presynaptic membrane|
|positive regulation of phospholipase activity|
|positive regulation of fat cell differentiation|
|negative regulation of synaptic transmission|
|regulation of catecholamine secretion|
|calcium ion transmembrane import into cytosol|
|regulation of synaptic transmission, glutamatergic|
|positive regulation of blood circulation|
|phosphatidylinositol-mediated signaling|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|calcium ion transport into cytosol|
|inositol lipid-mediated signaling|
|caveola|
|sensory perception of pain|
|virus receptor activity|
|response to anesthetic|
|regulation of synaptic vesicle exocytosis|
|positive regulation of lipid biosynthetic process|
|positive regulation of carbohydrate metabolic process|
|regulation of glycolytic process|
|regulation of phospholipid metabolic process|
|cellular response to dopamine|
|response to dopamine|
|regulation of carbohydrate catabolic process|
|cytosolic calcium ion transport|
|signal transduction involved in cellular response to ammonium ion|
|regulation of amine transport|
|viral entry into host cell|
|regulation of potassium ion transport|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of lipase activity|
|regulation of response to drug|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|entry into host|
|entry into host cell|
|regulation of neurotransmitter secretion|
|response to catecholamine|
|response to monoamine|
|regulation of synaptic vesicle cycle|
|response to alkaloid|
|regulation of purine nucleotide metabolic process|
|memory|
|regulation of nucleotide metabolic process|
|detection of external stimulus|
|regulation of ATP metabolic process|
|detection of abiotic stimulus|
|regulation of fat cell differentiation|
|regulation of sequestering of calcium ion|
|cellular response to ammonium ion|
|positive regulation of small molecule metabolic process|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|positive regulation of lipid metabolic process|
|regulation of neurotransmitter transport|
|adult behavior|
|negative regulation of ion transport|
|interaction with host|
|regulation of generation of precursor metabolites and energy|
|regulation of regulated secretory pathway|
|sensory perception of mechanical stimulus|
|vascular process in circulatory system|
|response to temperature stimulus|
|response to ammonium ion|
|regulation of lipid biosynthetic process|
|positive regulation of peptidyl-tyrosine phosphorylation|
|calcium ion transmembrane transport|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|positive regulation of ERK1 and ERK2 cascade|
|response to mechanical stimulus|
|regulation of exocytosis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|calcium ion transport|
|muscle contraction|
|cytoplasmic vesicle|
|regulation of peptidyl-tyrosine phosphorylation|
|learning or memory|
|positive regulation of MAP kinase activity|
|protein-containing complex binding|
|aging|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|regulation of ERK1 and ERK2 cascade|
|axon|
|divalent metal ion transport|
|cognition|
|muscle system process|
|response to xenobiotic stimulus|
|divalent inorganic cation transport|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of cellular catabolic process|
|neuronal cell body|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|regulation of lipid metabolic process|
|cellular response to drug|
|anterograde trans-synaptic signaling|
|dendrite|
|chemical synaptic transmission|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|detection of stimulus involved in sensory perception|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|behavior|
|positive regulation of kinase activity|
|regulation of system process|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|detection of stimulus|
|regulation of ion transport|
|viral process|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|protein localization to organelle|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|symbiotic process|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|interspecies interaction between organisms|
|cation transport|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|cellular homeostasis|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|ion transmembrane transport|
|positive regulation of cell differentiation|
|sensory perception|
|regulation of transferase activity|
|regulation of catabolic process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|cell death|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|transmembrane transport|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
No hits were found.
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 7149
* **Expression level (log2 read counts)**: 0.11
{{:chemogenomics:nalm6 dist.png?nolink |}}