======= HTR2C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HTR2C
  * **<color #00a2e8>Official Name</color>**: 5-hydroxytryptamine receptor 2C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3358|3358]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28335|P28335]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HTR2C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HTR2C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/312861|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1- 2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis. {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Gq/11-coupled serotonin receptor activity|
|phospholipase C-activating serotonin receptor signaling pathway|
|1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|
|regulation of corticotropin-releasing hormone secretion|
|positive regulation of phosphatidylinositol biosynthetic process|
|regulation of phosphatidylinositol biosynthetic process|
|serotonin binding|
|positive regulation of phospholipid biosynthetic process|
|regulation of phospholipid biosynthetic process|
|regulation of appetite|
|cGMP-mediated signaling|
|behavioral fear response|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|behavioral defense response|
|fear response|
|G protein-coupled serotonin receptor activity|
|G protein-coupled serotonin receptor signaling pathway|
|neurotransmitter receptor activity|
|serotonin receptor signaling pathway|
|positive regulation of phospholipid metabolic process|
|release of sequestered calcium ion into cytosol|
|drug binding|
|negative regulation of sequestering of calcium ion|
|positive regulation of fat cell differentiation|
|calcium ion transmembrane import into cytosol|
|multicellular organismal response to stress|
|calcium ion transport into cytosol|
|positive regulation of lipid biosynthetic process|
|regulation of phospholipid metabolic process|
|cellular response to dopamine|
|feeding behavior|
|response to dopamine|
|cytosolic calcium ion transport|
|signal transduction involved in cellular response to ammonium ion|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|response to monoamine|
|response to catecholamine|
|regulation of fat cell differentiation|
|regulation of sequestering of calcium ion|
|cellular response to ammonium ion|
|regulation of nervous system process|
|positive regulation of lipid metabolic process|
|regulation of neurotransmitter transport|
|cyclic-nucleotide-mediated signaling|
|response to ammonium ion|
|regulation of lipid biosynthetic process|
|locomotory behavior|
|calcium ion transmembrane transport|
|regulation of peptide hormone secretion|
|positive regulation of ERK1 and ERK2 cascade|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|calcium ion transport|
|regulation of hormone secretion|
|positive regulation of cytosolic calcium ion concentration|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|regulation of lipid metabolic process|
|cellular response to drug|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|behavior|
|regulation of system process|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|cellular homeostasis|
|response to organic cyclic compound|
|ion transmembrane transport|
|positive regulation of cell differentiation|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|defense response|
|positive regulation of developmental process|
|ion transport|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17269
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HTR2C Expression in NALM6 Cells: -2.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>