======= HTR6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HTR6
  * **<color #00a2e8>Official Name</color>**: 5-hydroxytryptamine receptor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3362|3362]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50406|P50406]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HTR6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HTR6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601109|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611). {ECO:0000250|UniProtKB:P31388, ECO:0000250|UniProtKB:Q9R1C8, ECO:0000269|PubMed:23027611}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histamine receptor activity|
|G protein-coupled serotonin receptor activity|
|G protein-coupled serotonin receptor signaling pathway|
|neurotransmitter receptor activity|
|positive regulation of TOR signaling|
|serotonin receptor signaling pathway|
|cerebral cortex cell migration|
|telencephalon cell migration|
|forebrain cell migration|
|cellular response to dopamine|
|response to dopamine|
|signal transduction involved in cellular response to ammonium ion|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|regulation of TOR signaling|
|response to catecholamine|
|response to monoamine|
|cerebral cortex development|
|cellular response to ammonium ion|
|pallium development|
|response to ammonium ion|
|cilium|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|telencephalon development|
|forebrain development|
|cellular response to drug|
|anterograde trans-synaptic signaling|
|dendrite|
|chemical synaptic transmission|
|trans-synaptic signaling|
|synaptic signaling|
|cellular response to organic cyclic compound|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|G protein-coupled receptor activity|
|brain development|
|head development|
|response to organic cyclic compound|
|cell migration|
|central nervous system development|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|response to drug|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.77|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9469
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HTR6 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>