======= ID1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ID1
  * **<color #00a2e8>Official Name</color>**: inhibitor of DNA binding 1, HLH protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3397|3397]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41134|P41134]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ID1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ID1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600349|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell-abiotic substrate adhesion|
|negative regulation of transcription by transcription factor localization|
|negative regulation of protein homodimerization activity|
|lung vasculature development|
|negative regulation of endothelial cell differentiation|
|endothelial cell morphogenesis|
|negative regulation of dendrite morphogenesis|
|proteasome binding|
|regulation of protein homodimerization activity|
|negative regulation of dendrite development|
|blood vessel endothelial cell migration|
|regulation of endothelial cell differentiation|
|epithelial cell morphogenesis|
|negative regulation of epithelial cell differentiation|
|cellular response to epidermal growth factor stimulus|
|lung morphogenesis|
|negative regulation of osteoblast differentiation|
|protein destabilization|
|negative regulation of cold-induced thermogenesis|
|response to epidermal growth factor|
|cellular response to nerve growth factor stimulus|
|endothelial cell development|
|response to nerve growth factor|
|negative regulation of DNA binding|
|protein self-association|
|positive regulation of actin filament bundle assembly|
|RNA polymerase II transcription factor binding|
|collagen metabolic process|
|endothelial cell migration|
|negative regulation of ossification|
|endothelial cell differentiation|
|epithelial cell migration|
|cellular response to dopamine|
|epithelium migration|
|response to dopamine|
|BMP signaling pathway|
|regulation of dendrite morphogenesis|
|regulation of actin filament bundle assembly|
|tissue migration|
|endothelium development|
|negative regulation of cell morphogenesis involved in differentiation|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|transforming growth factor beta receptor signaling pathway|
|negative regulation of protein binding|
|response to BMP|
|cellular response to BMP stimulus|
|response to monoamine|
|response to catecholamine|
|protein N-terminus binding|
|regulation of osteoblast differentiation|
|regulation of DNA binding|
|cellular response to ammonium ion|
|regulation of epithelial cell differentiation|
|circadian rhythm|
|regulation of cold-induced thermogenesis|
|regulation of dendrite development|
|negative regulation of neuron projection development|
|cellular response to transforming growth factor beta stimulus|
|negative regulation of DNA-binding transcription factor activity|
|response to transforming growth factor beta|
|lung development|
|negative regulation of binding|
|ameboidal-type cell migration|
|respiratory tube development|
|negative regulation of cell projection organization|
|cell-substrate adhesion|
|response to ammonium ion|
|protein C-terminus binding|
|positive regulation of epithelial cell proliferation|
|regulation of ossification|
|epithelial cell development|
|respiratory system development|
|positive regulation of supramolecular fiber organization|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of protein binding|
|positive regulation of cytoskeleton organization|
|negative regulation of neuron differentiation|
|regulation of actin filament organization|
|rhythmic process|
|regulation of protein stability|
|regulation of angiogenesis|
|negative regulation of neurogenesis|
|response to antibiotic|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|angiogenesis|
|regulation of vasculature development|
|cellular response to peptide|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|negative regulation of cell development|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of binding|
|regulation of actin filament-based process|
|cellular response to drug|
|blood vessel morphogenesis|
|regulation of DNA-binding transcription factor activity|
|response to peptide|
|blood vessel development|
|regulation of cell morphogenesis|
|centrosome|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|vasculature development|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|heart development|
|response to growth factor|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|cell morphogenesis involved in differentiation|
|cellular response to organonitrogen compound|
|positive regulation of organelle organization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|tube morphogenesis|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|regulation of MAPK cascade|
|head development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|central nervous system development|
|Golgi apparatus|
|negative regulation of cell death|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|cell development|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|tissue development|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12020
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ID1 Expression in NALM6 Cells: -0.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>