======= ID3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ID3
  * **<color #00a2e8>Official Name</color>**: inhibitor of DNA binding 3, HLH protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3399|3399]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02535|Q02535]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ID3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ID3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600277|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. {ECO:0000269|PubMed:8437843}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leptomycin B binding|
|response to leptomycin B|
|cellular response to leptomycin B|
|notochord development|
|negative regulation of myoblast differentiation|
|negative regulation of osteoblast differentiation|
|regulation of myoblast differentiation|
|negative regulation of DNA binding|
|cellular response to fatty acid|
|RNA polymerase II transcription factor binding|
|negative regulation of ossification|
|metanephros development|
|response to fatty acid|
|regulation of DNA replication|
|regulation of osteoblast differentiation|
|cellular response to antibiotic|
|odontogenesis|
|regulation of DNA binding|
|circadian rhythm|
|protein dimerization activity|
|negative regulation of DNA-binding transcription factor activity|
|negative regulation of binding|
|regulation of ossification|
|cellular response to acid chemical|
|negative regulation of neuron differentiation|
|transcription corepressor activity|
|protein domain specific binding|
|kidney development|
|rhythmic process|
|renal system development|
|negative regulation of neurogenesis|
|muscle organ development|
|response to antibiotic|
|negative regulation of nervous system development|
|urogenital system development|
|transcription factor binding|
|negative regulation of cell development|
|response to acid chemical|
|regulation of binding|
|regulation of DNA-binding transcription factor activity|
|embryonic organ development|
|muscle structure development|
|cellular response to lipid|
|heart development|
|cellular response to organic cyclic compound|
|response to wounding|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|regulation of neuron differentiation|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|neuron differentiation|
|cellular response to oxygen-containing compound|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.44|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.27|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.24|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.18|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-2.06|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.97|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.87|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.85|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.82|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.79|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.75|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.75|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.76|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.81|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.82|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.87|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.89|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.9|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.95|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.03|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.06|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.07|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.07|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.1|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.11|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.19|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.22|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.39|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.43|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.66|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|3|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|3.1|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.25|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.28|
|[[:results:exp59|UMK57 1μM R01 exp59]]|3.59|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|5.92|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|5.99|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|6.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nsd1|NSD1]]|0.756|
|[[:human genes:b:bap1|BAP1]]|0.672|
|[[:human genes:d:dohh|DOHH]]|0.621|
|[[:human genes:r:rptor|RPTOR]]|0.606|
|[[:human genes:t:trim28|TRIM28]]|0.602|
|[[:human genes:c:ccdc101|CCDC101]]|0.601|
|[[:human genes:c:cbfb|CBFB]]|0.598|
|[[:human genes:r:runx1|RUNX1]]|0.595|
|[[:human genes:z:znf592|ZNF592]]|0.573|
|[[:human genes:a:asxl2|ASXL2]]|0.563|
|[[:human genes:t:tle4|TLE4]]|0.562|
|[[:human genes:b:brpf1|BRPF1]]|0.557|
|[[:human genes:t:trim33|TRIM33]]|0.555|
|[[:human genes:w:wdr24|WDR24]]|0.555|
|[[:human genes:m:mtor|MTOR]]|0.547|
|[[:human genes:u:usp22|USP22]]|0.542|
|[[:human genes:s:ssbp2|SSBP2]]|0.541|
|[[:human genes:m:maml1|MAML1]]|0.54|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.539|
|[[:human genes:z:zmym2|ZMYM2]]|0.527|
|[[:human genes:m:mlst8|MLST8]]|0.521|
|[[:human genes:z:zfx|ZFX]]|0.516|
|[[:human genes:a:atf7ip|ATF7IP]]|0.51|
|[[:human genes:l:ldb1|LDB1]]|0.504|
|[[:human genes:s:setdb1|SETDB1]]|0.504|
|[[:human genes:i:id4|ID4]]|0.501|
|[[:human genes:u:ube2g2|UBE2G2]]|0.497|
|[[:human genes:m:med23|MED23]]|0.494|
|[[:human genes:x:xpo6|XPO6]]|0.491|
|[[:human genes:l:lmo2|LMO2]]|0.491|
|[[:human genes:s:scaf8|SCAF8]]|0.488|
|[[:human genes:c:cbx3|CBX3]]|0.488|
|[[:human genes:d:ddx5|DDX5]]|0.484|
|[[:human genes:f:fbxo11|FBXO11]]|0.484|
|[[:human genes:o:otud5|OTUD5]]|0.483|
|[[:human genes:g:gltscr1l|GLTSCR1L]]|0.481|
|[[:human genes:s:sox7|SOX7]]|0.476|
|[[:human genes:i:irf2bp1|IRF2BP1]]|0.476|
|[[:human genes:t:taf5l|TAF5L]]|0.473|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.472|
|[[:human genes:v:vhl|VHL]]|0.468|
|[[:human genes:a:asb7|ASB7]]|0.461|
|[[:human genes:a:aars|AARS]]|0.454|
|[[:human genes:f:faf2|FAF2]]|0.454|
|[[:human genes:t:trip12|TRIP12]]|0.452|
|[[:human genes:a:ago2|AGO2]]|0.45|
|[[:human genes:h:hhex|HHEX]]|0.449|
|[[:human genes:d:dcaf5|DCAF5]]|0.448|
|[[:human genes:e:eny2|ENY2]]|0.446|
|[[:human genes:s:supt7l|SUPT7L]]|0.445|
|[[:human genes:u:ube2l3|UBE2L3]]|0.444|
|[[:human genes:t:tmem41b|TMEM41B]]|0.443|
|[[:human genes:t:tp53|TP53]]|0.443|
|[[:human genes:c:celf1|CELF1]]|0.439|
|[[:human genes:a:arl14ep|ARL14EP]]|0.439|
|[[:human genes:m:mef2c|MEF2C]]|0.438|
|[[:human genes:a:actb|ACTB]]|0.438|
|[[:human genes:h:helz|HELZ]]|0.435|
|[[:human genes:z:zmiz1|ZMIZ1]]|0.435|
|[[:human genes:t:tada2b|TADA2B]]|0.435|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.434|
|[[:human genes:b:brd9|BRD9]]|0.433|
|[[:human genes:z:znf608|ZNF608]]|0.432|
|[[:human genes:m:mllt1|MLLT1]]|0.429|
|[[:human genes:r:rnmt|RNMT]]|0.429|
|[[:human genes:o:opa1|OPA1]]|0.425|
|[[:human genes:h:hars|HARS]]|0.422|
|[[:human genes:b:bptf|BPTF]]|0.42|
|[[:human genes:h:hccs|HCCS]]|0.416|
|[[:human genes:t:thg1l|THG1L]]|0.416|
|[[:human genes:w:wdr59|WDR59]]|0.416|
|[[:human genes:u:ube2k|UBE2K]]|0.416|
|[[:human genes:z:zbtb44|ZBTB44]]|0.415|
|[[:human genes:d:dpagt1|DPAGT1]]|0.412|
|[[:human genes:s:ssb|SSB]]|0.411|
|[[:human genes:s:sec63|SEC63]]|0.411|
|[[:human genes:t:trmt10a|TRMT10A]]|0.411|
|[[:human genes:m:mios|MIOS]]|0.411|
|[[:human genes:g:gmppb|GMPPB]]|0.409|
|[[:human genes:s:serf2|SERF2]]|0.409|
|[[:human genes:l:lsm11|LSM11]]|0.409|
|[[:human genes:e:erg|ERG]]|0.408|
|[[:human genes:d:dr1|DR1]]|0.408|
|[[:human genes:l:lyl1|LYL1]]|0.407|
|[[:human genes:m:med25|MED25]]|0.407|
|[[:human genes:m:meaf6|MEAF6]]|0.407|
|[[:human genes:u:uap1|UAP1]]|0.406|
|[[:human genes:k:kdm6b|KDM6B]]|0.406|
|[[:human genes:e:egln1|EGLN1]]|0.404|
|[[:human genes:t:tada3|TADA3]]|0.402|
|[[:human genes:d:dnajc3|DNAJC3]]|0.401|
|[[:human genes:b:bak1|BAK1]]|0.401|
|[[:human genes:s:sp3|SP3]]|0.4|
|[[:human genes:t:tti1|TTI1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1498
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ID3 Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>