======= IDUA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IDUA
  * **<color #00a2e8>Official Name</color>**: alpha-L-iduronidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3425|3425]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35475|P35475]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IDUA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IDUA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/252800|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco hydro 39|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-iduronidase activity|
|heparin catabolic process|
|dermatan sulfate catabolic process|
|coated vesicle|
|heparin metabolic process|
|disaccharide metabolic process|
|dermatan sulfate metabolic process|
|chondroitin sulfate catabolic process|
|dermatan sulfate proteoglycan metabolic process|
|chondroitin sulfate metabolic process|
|chondroitin sulfate proteoglycan metabolic process|
|oligosaccharide metabolic process|
|sulfur compound catabolic process|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|proteoglycan metabolic process|
|lysosomal lumen|
|mucopolysaccharide metabolic process|
|monocarboxylic acid catabolic process|
|drug catabolic process|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|cellular carbohydrate metabolic process|
|carbohydrate derivative catabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|signaling receptor binding|
|sulfur compound metabolic process|
|glycoprotein metabolic process|
|small molecule catabolic process|
|carbohydrate metabolic process|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7929
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IDUA Expression in NALM6 Cells: 3.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>