======= IFITM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFITM1
  * **<color #00a2e8>Official Name</color>**: interferon induced transmembrane protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8519|8519]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13164|P13164]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFITM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFITM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604456|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. {ECO:0000269|PubMed:16847454, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20838853, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:22634173}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CD225|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of viral entry into host cell|
|response to interferon-alpha|
|response to interferon-beta|
|regulation of viral entry into host cell|
|negative regulation of viral genome replication|
|positive regulation of osteoblast differentiation|
|cellular response to type I interferon|
|type I interferon signaling pathway|
|response to type I interferon|
|negative regulation of viral life cycle|
|positive regulation of ossification|
|regulation of viral genome replication|
|negative regulation of viral process|
|regulation of osteoblast differentiation|
|regulation of viral life cycle|
|response to interferon-gamma|
|regulation of ossification|
|defense response to virus|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of cell migration|
|ossification|
|negative regulation of cell motility|
|response to virus|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|protein-containing complex|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|innate immune response|
|regulation of multi-organism process|
|regulation of cell migration|
|regulation of cell motility|
|defense response to other organism|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|immune effector process|
|response to cytokine|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.73|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.78|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.451|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5222
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFITM1 Expression in NALM6 Cells: -0.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>